Dopamine scales performance in the absence of new learning
Dopamine scales performance in the absence of new learning
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DOI：
10.1016/j.neuron.2006.07.026
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发表时间：
2006-09-07
期刊：
影响因子：
16.2
通讯作者：
Zhuang, Xiaoxi
中科院分区：
文献类型：
--
作者：
Cagniard, Barbara;Beeler, Jeff A.;Zhuang, Xiaoxi
学习和动机在形成生物体的适应性行为中是不可或缺的。多巴胺系统参与了这两个过程；然而，分离两者，无论是实验还是概念，都提出了重大挑战。我们开发了一种动物模型，将习得行为的表达或缩放与学习本身分离开来。诱导型多巴胺转运蛋白（DAT）敲低小鼠系显示释放的多巴胺再摄取明显减慢，多巴胺神经元的强直性放电增加，但不改变相爆发放电。小鼠在诱导高多巴胺能张力之前接受实验任务训练，然后再进行测试。多巴胺水平提高了目标导向操作反应的表现。这些数据表明，多巴胺能音调的改变可以在没有新学习的情况下扩大先前学习行为的表现。
Learning and motivation are integral in shaping an organism's adaptive behavior. The dopamine system has been implicated in both processes; however, dissociating the two, both experimentally and conceptually, has posed significant challenges. We have developed an animal model that dissociates expression or scaling of a learned behavior from learning itself. An inducible dopamine transporter (DAT) knockdown mouse line has been generated, which exhibits significantly slower reuptake of released dopamine and increased tonic firing of dopamine neurons without altering phasic burst firing. Mice were trained in experimental tasks prior to inducing a hyperdopaminergic tone and then retested. Elevated dopamine enhanced performance in goal-directed operant responses. These data demonstrate that alterations in dopaminergic tone can scale the performance of a previously learned behavior in the absence of new learning.