Outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in Shaanxi, China
Outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in Shaanxi, China
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DOI：
10.1111/1348-0421.12074
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发表时间：
2013-08-01
影响因子：
2.6
通讯作者：
Xu, Jiru
中科院分区：
文献类型：
--
作者：
Yu, Pengbo;Ma, Chaofeng;Xu, Jiru
在许多国家的军队人群中报告了与HAdV相关的ARD爆发。在这里，我们报告了2012年2月至3月在中国陕西省军事训练营发生的由HAdV-7引起的ARD爆发。收集流行病学资料和患者标本，对标本和病毒分离株进行病毒核苷酸检测和测序。检测抗HAdV的IgG和伊加抗体，以及抗本次暴发分离毒株的中和抗体。流行病学研究表明，所有受影响的人员均为男性，平均年龄为19.1岁。两个峰值出现在曲线上，峰值之间有8天的间隔。对临床标本进行核酸检测，HAdV阳性率为83.33%（15/18）。通过血清抗体检测、病毒分离和系统发育分析，进一步证实HAdV-7是此次暴发的病原体。伊加抗体于发病后第4天开始出现，第8天100%阳性。本次疫情的病毒株与2009年陕西汉中分离的病毒高度相似。我们认为HAdV-7是此次暴发的病原体，这是首次在中国军队人群中报道的由HAdV-7引起的ARD暴发。应重视疫苗的开发，以及加强流行病学和病毒学监测的HAdV感染在中国。
Outbreaks of ARD associated with HAdV have been reported in military populations in many countries. Here, we report an ARD outbreak caused by HAdV-7 in a military training camp in Shaanxi Province, China, from February to March of 2012. Epidemic data and samples from the patients were collected, and viral nucleotides from samples and viral isolations were detected and sequenced. IgG and IgA antibodies against HAdV, and the neutralization antibodies against the viral strain isolated in this outbreak, were detected. Epidemiological study showed that all personnel affected were males with an average age of 19.1 years. Two peaks appeared on the epicurve and there was an 8-day interval between peaks. Laboratory results of viral nucleotide detection carried out with clinical specimens were positive for HAdV (83.33%, 15/18). Further study through serum antibody assay, virus isolation and phylogenetic analysis showed that HAdV-7 was the etiological agent responsible for the outbreak. IgA antibody began to appear on the 4th day after the onset and showed 100% positivity on the 8th day. The virus strain in the present outbreak was highly similar to the virus isolated in Hanzhong Shaanxi in 2009. We conclude that HAdV-7 was the pathogen corresponding to the outbreak, and this is the first report of an ARD outbreak caused by HAdV-7 in military persons in China. Vaccine development, as well as enhanced epidemiological and virological surveillance of HAdV infections in China should be emphasized.