Stimulant Self-Administration
Stimulant Self-Administration
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DOI：
10.1007/978-1-60761-934-5_2
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发表时间：
2011-01-01
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影响因子：
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通讯作者：
Panlilio, Leigh V.
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作者：
Panlilio, Leigh V.
可卡因和安非他明等兴奋剂因其奖励作用而被广泛滥用。我们对药物滥用和药物奖励的了解大部分来自于涉及兴奋剂的研究，其中大部分研究涉及使用药物自我管理作为药物滥用的动物模型。本章以兴奋剂自我给药为例说明：（1）药物自我给药程序的基本方法学;（2）适用于成瘾和成瘾动物模型的行为原则。已经开发了许多自我给药程序的变体，以模拟药物滥用的特定方面，评估药物的奖励作用，并评估治疗效果。本章描述了如何通过规定接受药物的行为要求来设计这些变化（即，强化的时间表），并纳入类似于人类药物滥用环境中发生的药物相关环境线索。
Stimulants such as cocaine and the amphetamines are widely abused due to their rewarding effects. Much of what we know about drug abuse and drug reward comes from research involving stimulants, and much of this research involves using drug self-administration as an animal model of drug abuse. In this chapter, the example of stimulant self-administration is used to illustrate: (1) the basic methodology of drug self-administration procedures and (2) the behavioral principles that apply to addiction and animal models of addiction. Many variations of the self-administration procedure have been developed to model specific aspects of drug abuse, to assess the rewarding effects of drugs, and to assess the effects of treatments. The chapter describes how these variations are devised by stipulating the behavioral requirements for receiving the drug (i.e., the schedule of reinforcement) and incorporating drug-related environmental cues analogous to those that Occur in the human drug-abuse environment.