Puffball‐Inspired Microrobotic Systems with Robust Payload, Strong Protection, and Targeted Locomotion for On‐Demand Drug Delivery
Puffball‐Inspired Microrobotic Systems with Robust Payload, Strong Protection, and Targeted Locomotion for On‐Demand Drug Delivery
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受马勃启发的微型机器人系统，具有强大的有效负载、强大的保护和针对按需药物输送的定向运动
DOI：
10.1002/adma.202204791
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发表时间：
2022
影响因子：
29.4
通讯作者：
M. Stevens
中科院分区：
文献类型：
--
作者：
Xin Song;Rujie Sun;Richard Wang;K. Zhou;Ruoxiao Xie;Junliang Lin;D. Georgiev;Andrei;Ruibo Zhao;M. Stevens
微型机器人被认为是药物输送系统（DDS）的变革性解决方案，因为它们可以通过身体导航到特定位置并实现靶向药物释放。然而，它们的实现受到有效载荷能力不足、不可避免的药物泄漏/失活以及药物的严格修饰/稳定性标准的极大限制。天然马勃具有迷人的功能，是非常可取的DDS，包括一个大的子实体存储孢子，灵活的保护帽，和环境触发释放机制。本报告介绍了一种马勃启发的微型机器人系统，该系统包括一个用于装载大量药物和空间药物分离的内室，以及一个近红外响应顶部密封层，提供强大的药物保护和按需释放。这些受马勃启发的微型机器人（PIM）显示出可调的负载能力，可达到高浓度，并增强了药物保护，药物泄漏最小。在近红外激光照射下，实现了具有快速释放效率的按需药物递送。PIM还展示了平移运动速度，可切换的运动模式，以及在旋转磁场下的精确运动。这项工作为DDS提供了强有力的概念验证，该DDS将微型机器人的上级运动能力与马勃的独特特性相结合，从而说明了开发新一代微型机器人用于靶向药物递送的多功能途径。
Microrobots are recognized as transformative solutions for drug delivery systems (DDSs) because they can navigate through the body to specific locations and enable targeted drug release. However, their realization is substantially limited by insufficient payload capacity, unavoidable drug leakage/deactivation, and strict modification/stability criteria for drugs. Natural puffballs possess fascinating features that are highly desirable for DDSs, including a large fruitbody for storing spores, a flexible protective cap, and environmentally triggered release mechanisms. This report presents a puffball‐inspired microrobotic system which incorporates an internal chamber for loading large drug quantities and spatial drug separation, and a near‐infrared‐responsive top‐sealing layer offering strong drug protection and on‐demand release. These puffball‐inspired microrobots (PIMs) display tunable loading capacities up to high concentrations and enhanced drug protection with minimal drug leakage. Upon near‐infrared laser irradiation, on‐demand drug delivery with rapid release efficiency is achieved. The PIMs also demonstrate translational motion velocities, switchable motion modes, and precise locomotion under a rotating magnetic field. This work provides strong proof‐of‐concept for a DDS that combines the superior locomotion capability of microrobots with the unique characteristics of puffballs, thereby illustrating a versatile avenue for development of a new generation of microrobots for targeted drug delivery.