Simian immunodeficiency virus of African green monkeys is apathogenic in the newborn natural host
Simian immunodeficiency virus of African green monkeys is apathogenic in the newborn natural host
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DOI：
10.1097/00042560-199807010-00003
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发表时间：
1998-07-01
期刊：
影响因子：
--
通讯作者：
Kurth, R
中科院分区：
文献类型：
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作者：
Beer, B;Denner, J;Kurth, R
几项研究表明，新生动物在感染逆转录病毒后比成年动物更容易发病。感染SIVagm的成年非洲绿猴（AGMs）不会发展成艾滋病样疾病，本研究的目的是确定实验性感染SIVagm的新生非洲绿猴是否会导致发病。发现新生儿agm的循环CD4（+）淋巴细胞百分比高于成人（62%对14%），因此SIVagm感染的潜在靶细胞池更高。然而，SIVagm在成人和新生儿AGMs外周血单个核细胞中的体外复制动力学并没有观察到差异。在体内，新生的AGMs在接种后最早两个月就变成病毒血症，而成年AGMs在感染后2至6周就有病毒复制的证据。没有一只动物在感染后出现类似艾滋病的症状。在异源食蟹猕猴宿主中，感染SIVagm的新生儿出现早期高病毒载量，并在出生2个月后死亡，伴有艾滋病样组织病理特征。因此，与许多其他逆转录病毒的情况相反，新生儿agm对SIVagm的容受性并不比成人强。
Several studies have demonstrated that newborn animals are more susceptible to disease development following infection with retroviruses than adults. Adult African green monkeys (AGMs) infected with SIVagm do not develop AIDS-like disease and the objective of the study was to determine whether experimental infection of newborn AGMs with SIVagm would result in pathogenesis. Neonatal AGMs were found to have a higher percentage of circulating CD4(+) lymphocytes than adults (62% versus 14%) and therefore a higher potential pool of target cells for SIVagm infection. However, no differences in the in vitro replication kinetics of SIVagm in peripheral blood mononuclear cells of adult or neonatal AGMs could be observed. In vivo, the neonatal AGMs became viremic at the earliest two months after inoculation whereas the adult AGMs had evidence of virus replication already 2 to 6 weeks after infection. None of the animals developed AIDS-like symptoms upon infection. In the heterologous cynomolgus macaque host, a newborn infected with SIVagm developed early high virus loads and died two months after birth with AIDS-like histopathologic features. It would therefore appear that in contrast to the situation with many other retroviruses, newborn AGMs are no more permissive to SIVagm than are adults.