A pilot prospective study of fetomaternal hemorrhage identified by anemia in asymptomatic neonates.
A pilot prospective study of fetomaternal hemorrhage identified by anemia in asymptomatic neonates.
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DOI：
10.1038/jp.2015.211
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Plafkin C
中科院分区：
文献类型：
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作者：
Stroustrup A;Plafkin C
胎儿母体出血（FMH）是一种知之甚少的疾病，其中胎儿红细胞通过缺陷的胎盘屏障转移到母体循环中。关于FMH在一般妊娠人群中的真实发病率、流行病学或病理生理学知之甚少，因为现有研究是基于回顾性队列研究和明显的诊断和选择偏倚。评价基于产前母体血液检测和新生儿贫血在一般人群中进行母胎出血前瞻性研究的可行性。前瞻性队列研究。19名孕妇在20名健康婴儿足月分娩前入组。5名新生儿在第一次产后检测时意外出现贫血。与5名贫血新生儿中的2名相关的孕妇血液样本具有阳性Kleihauer-Betke试验，而出生后血细胞计数正常的新生儿没有相关的异常Kleihauer-Betke试验。具有临床意义的FMH可能比以前认为的更常见。FMH的前瞻性流行病学研究是可行的。
Fetomaternal hemorrhage (FMH) is a poorly understood condition in which fetal erythrocytes transfer to the maternal circulation via a faulty placental barrier. Little is known about the true incidence, epidemiology, or pathophysiology of FMH in the general pregnant population as existing studies are based on retrospective cohorts and manifest diagnosis and selection bias. To evaluate the practicability of a prospective study of fetomaternal hemorrhage in the general population based on antepartum maternal blood testing and neonatal anemia. Prospective cohort study. Nineteen pregnant women were enrolled prior to the term delivery of twenty well infants. Five neonates were unexpectedly anemic on first postnatal testing. Antenatal maternal blood samples associated with 2 of 5 anemic newborns had positive Kleihauer-Betke testing while no newborn with a normal postnatal blood count had an associated abnormal Kleihauer-Betke test. Clinically significant FMH may be more common than previously thought. Prospective epidemiological study of FMH is feasible.