The synergism between hyperthermia and ionising radiation.
The synergism between hyperthermia and ionising radiation.
复制标题
热疗和电离辐射之间的协同作用。
DOI：
--
复制
发表时间：
1986
影响因子：
2.6
通讯作者：
R. W. Stanford
中科院分区：
文献类型：
--
作者：
J. Holt;R. W. Stanford
辐照细胞的实验存活曲线可以表示为，在剂量D后，初始群体为N0，有N个幸存者，D0是每个靶标一次“击中”所需的剂量，N个靶标被辐照（Johns, 1964）。当将临床得出的D0和n值用于该方程时，得到的曲线与实验结果吻合（Andrews, 1968）。影响D0和/或n的因素改变了给定剂量d下n /N0的比率。高压氧是其中一个因素（Deschmer & Gray, 1959; Gray, 1961），另一个因素是受辐照细胞温度的升高（Dewey & Freeman, 1980）。后一种效应所产生的变化是朝着有利的方向发展的（韦斯特拉，1971）。为了使这种变化在临床上有效，热疗结合电离辐射必须既不会对正常组织产生毒性，也不会增加正常组织的x射线剂量的发病率。在人体肝脏的极限温度41.8°C下，对正常组织没有明显的危害（Law & Pettigrew, 1980）。
The experimental survival curve for irradiated cells can be represented by where there are N survivors from an initial population of N0 after dose D, D0 is the dose required for one “hit” per target and n targets are irradiated (Johns, 1964). When clinically derived values of D0 and n are used in this equation the resulting curve fits experimental results (Andrews, 1968). Factors affecting D0 and/or n change the ratio N/N0 for a given dose D. Hyperbaric oxygen is one such factor (Deschmer & Gray, 1959; Gray, 1961) and a rise in the temperature of the irradiated cells another (Dewey & Freeman, 1980). The change produced by this latter effect is in a favourable direction (Westra, 1971). For this change to be clinically valid, hyperthermia in conjunction with ionising radiation must neither be toxic to normal tissue nor increase the morbidity of the X-ray dose on normal tissue. At 41.8°C, the limiting temperature for human liver, there is no demonstrable harm to normal tissue (Law & Pettigrew, 1980) nor is t...