EARLY ONSET OF AGE-RELATED IMPAIRMENT OF AVERSIVE AND APPETITIVE LEARNING IN THE SAM-P/8 MOUSE
EARLY ONSET OF AGE-RELATED IMPAIRMENT OF AVERSIVE AND APPETITIVE LEARNING IN THE SAM-P/8 MOUSE
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DOI：
10.1093/geronj/47.2.b52
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发表时间：
1992-03-01
期刊：
影响因子：
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通讯作者：
MORLEY, JE
中科院分区：
文献类型：
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作者：
FLOOD, JF;MORLEY, JE
SAM-P/8（P/8 jf）小鼠，在厌恶和食欲训练任务的训练，表现出年龄相关的障碍，学习更困难的任务。 使用厌恶的训练任务，收购步下被动回避之间没有差异4个月和12个月大的小鼠。 T-迷宫足电击回避收购检测到9至12个月大的损害。 在食欲任务中，12个月大的小鼠比4个月大的小鼠需要更多的试验来学习按下杠杆以加强牛奶或学习10个黑白，左右辨别的特定序列。 然而，在同一个10个单位的迷宫中学习简单的黑白区分并没有区分4个月和12个月大的小鼠的表现。 缺乏与年龄相关的食物，水和牛奶消费的变化表明，动机的变化并不能解释老年P/8 jf小鼠学习能力的下降。 结果表明，相对于P/8 jf小鼠17.2个月的中位寿命，学习受损的发病较早。
SAM-P/8 (P/8jf) mice, trained on aversive and appetitive training tasks, showed age-related impairment of learning on more difficult tasks. Using aversive training tasks, acquisition of step-down passive avoidance did not differ between 4- and 12-month-old mice. T-maze footshock avoidance acquisition detected impairment from 9 to 12 months of age. On the appetitive tasks, 12-month-old mice required significantly more trials than 4-month-old mice to learn to press a lever for milk reinforcement or to learn a specific sequence of 10 black-white, left-right discriminations. However, learning a simple black-white discrimination in the same 10-unit maze did not discriminate between the performance of 4- and 12-month-old mice. A lack of age-related changes in food, water, and milk consumption suggests that changes in motivation do not account for the decline in learning in older P/8jf mice. The results suggest an early onset of impaired learning relative to the 17.2-month median life span of the P/8jf mice.