J-wave syndromes: Brugada and early repolarization syndromes.
J-wave syndromes: Brugada and early repolarization syndromes.
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DOI：
10.1016/j.hrthm.2015.04.014
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发表时间：
2015-08
期刊：
影响因子：
5.5
通讯作者：
Yan GX
中科院分区：
文献类型：
--
作者：
Antzelevitch C;Yan GX
在许多危及生命的心律失常综合征中会遇到突出的J波，包括Brugada（BrS）和早期复极（ERS）综合征。BrS和ERS在异常J波的幅度和导联位置方面不同，并被认为代表了称为J波综合征的表型表达的连续谱。尽管经过二十年的深入研究，这两种遗传性心律失常综合征的风险分层和治疗方法仍在快速发展。我们在这篇综述中的目的是提供一个综合的概要的临床特征，风险分层，以及分子，离子，细胞和遗传机制的基础上，这两个迷人的综合征，已捕获的兴趣和注意力的心脏病学社区在最近几年。
A prominent J wave is encountered in a number of life-threatening cardiac arrhythmia syndromes, including the Brugada (BrS) and early repolarization (ERS) syndromes. BrS and ERS differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. Despite two decades of intensive research, risk stratification and the approach to therapy of these two inherited cardiac arrhythmia syndromes are still undergoing rapid evolution. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, as well as the molecular, ionic, cellular and genetic mechanisms underlying these two fascinating syndromes that have captured the interest and attention of the cardiology community in recent years.