Lamina Cribrosa Depth Variation Measured by Spectral-Domain Optical Coherence Tomography Within and Between Four Glaucomatous Optic Disc Phenotypes
Lamina Cribrosa Depth Variation Measured by Spectral-Domain Optical Coherence Tomography Within and Between Four Glaucomatous Optic Disc Phenotypes
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DOI：
10.1167/iovs.14-15942
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发表时间：
2015-09-01
影响因子：
4.4
通讯作者：
Yoshitomi, Takeshi
中科院分区：
文献类型：
--
作者：
Sawada, Yu;Hangai, Masanori;Yoshitomi, Takeshi
目的。研究通过谱域光学相干断层扫描 (SD-OCT) 测量四种青光眼视乳头表型的筛板 (LC) 深度变化。在这项横断面研究中，59 只正常眼和 180 只开角型青光眼 (OAG) 眼被分为 56 只局灶性损伤视盘 (FI)、30 只视杯盘广泛增大 (GE)、69 只近视青光眼盘 (MY) 和 25 只老年硬化盘 (SS)。他们通过增强深度成像 SD-OCT 进行成像，获得多个水平和垂直视神经盘 B 扫描。相对于布鲁赫膜开口 (BMO) 和前巩膜 (AS) 参考平面测量平均和最大 LC 深度。比较正常组和 OAG 组椎间盘表型之间的筛板深度。检查组内筛板深度差异以及它们之间的重叠。结果。 OAG 组相对于 BMO 和 AS 参考平面的平均和最大 LC 深度大于正常组 (P < 0.0001)。在青光眼表型中，GE 组的平均 LC 深度和最大 LC 深度最大（P < 0.001），SS 组的平均和最大 LC 深度最小（P < 0.05）。正常组和SS组之间存在较大范围的LC深度重叠，并且很大比例的SS眼的LC深度在正常组的95%置信区间内。结论。与正常组相比，OAG 组的 LC 向后移位。四种青光眼视盘表型的 LC 深度存在显着差异。 SS组的LC深度与正常组相似。
PURPOSE. To study lamina cribrosa (LC) depth variation measured by spectral-domain optical coherence tomography (SD-OCT) in four glaucomatous optic disc phenotypes.METHODS. In this cross-sectional study, 59 normal eyes and 180 open-angle glaucoma (OAG) eyes were grouped into 56 focally injured discs (FI), 30 generalized enlargement of the optic cup discs (GE), 69 myopic glaucomatous discs (MY), and 25 senile sclerotic discs (SS). They were imaged by enhanced depth imaging SD-OCT, obtaining multiple horizontal and vertical optic disc B-scans. Mean and maximum LC depths were measured relative to Bruch's membrane opening (BMO) and the anterior sclera (AS) reference planes. Lamina cribrosa depths were compared between and among the normal and OAG group disc phenotypes. Lamina cribrosa depth differences within groups were examined as well as the overlap between them.RESULTS. Mean and maximum LC depths relative to the BMO and AS reference planes were greater in the OAG group than in the normal group (P < 0.0001). Among glaucomatous phenotypes, the GE group had the greatest (P < 0.001) and the SS group had the smallest (P < 0.05) mean and maximum LC depths. There was a wide range of LC depth overlap between the normal and SS groups, and a high proportion of SS eyes had LC depths within the 95% confidence interval of the normal group.CONCLUSIONS. The LC was displaced posteriorly in OAG group compared to the normal group. The LC depth was significantly different among four glaucomatous disc phenotypes. The LC depth of the SS group was similar to the normal group.