COCHLEAR PATHOLOGY FOLLOWING CHRONIC ELECTRICAL-STIMULATION USING NONCHARGE BALANCED STIMULI
COCHLEAR PATHOLOGY FOLLOWING CHRONIC ELECTRICAL-STIMULATION USING NONCHARGE BALANCED STIMULI
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DOI：
10.3109/00016489109138421
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发表时间：
1991-01-01
影响因子：
1.4
通讯作者：
CLARK, GM
中科院分区：
文献类型：
--
作者：
SHEPHERD, RK;MATSUSHIMA, J;CLARK, GM
在使用电荷平衡双相电流脉冲的慢性颅内电刺激研究过程中，一只动物无意中接受了约1 μ A水平的短时间直流电（DC）刺激。 随后，使用产生约2 μ A的DC电平的不良电荷平衡波形对动物进行慢性刺激。 在耳蜗内观察到广泛的病理变化。 这些变化包括广泛的螺旋神经节细胞损失和新骨生长，延伸到耳蜗的所有转弯处。 电诱发听性脑干反应（EABR）的形态学的显着变化与这些病理变化。 在DC刺激之前记录的EABR表现出正常的波形形态。 然而，在DC刺激的过程中记录的反应被认为是前庭起源的短潜伏期反应所主导。 反应阈值也显著高于DC刺激前记录的水平。 相反，对侧耳蜗，刺激使用电荷平衡刺激，没有表现出不利的病理变化的证据。 此外，从这个耳蜗诱发的EABR在整个慢性刺激期间保持稳定。 虽然是初步的，目前的结果说明了不良的电荷平衡电刺激的不利性质。 这些结果对神经假体的设计和使用DC刺激来抑制患者的耳鸣具有重要意义。
During the course of a chronic intracochlear electrical stimulation study using charge balanced biphasic current pulses, one animal inadvertently received a short period of direct current (DC) stimulation at a level of approximately 1-mu-A. Subsequent, the animal was chronically stimulated using a poorly charge balanced waveform that produced a DC level of approximately 2-mu-A. Extensive pathological changes were observed within the cochlea. These changes included widespread spiral ganglion cell loss and new bone growth that extended throughout all turns of the cochlea. Significant changes in the morphology of the electrically evoked auditory brainstem response (EABR) were associated with these pathological changes. EABRs recorded prior to the DC stimulation exhibited a normal waveform morphology. However, responses recorded during the course of the DC stimulation were dominated by a short latency response believed to be vestibular in origin. The response thresholds were also significantly higher than levels recorded before the DC stimulation. In contrast, the contralateral cochlea, stimulated using charge balanced stimuli, showed no evidence of adverse pathological changes. Furthermore, EABRs evoked from this cochlea remained stable throughout the chronic stimulation period. Although preliminary, the present results illustrate the adverse nature of poorly charge balanced electrical stimuli. These results have important implications for both the design of neural prostheses and the use of DC stimuli to suppress tinnitus in patients.