Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases
Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases
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DOI：
10.3324/haematol.2012.065375
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发表时间：
2012-12-01
期刊：
影响因子：
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通讯作者：
Haferlach, Torsten
中科院分区：
文献类型：
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作者：
Schnittger, Susanne;Bacher, Ulrike;Haferlach, Torsten
我们分析了636例不同类型的骨髓增生性肿瘤或骨髓增生异常/骨髓增殖性肿瘤的Casitas B细胞淋巴瘤基因(CBLmut)外显子8和9的突变，并与其他基因改变进行了相关性分析。636例患者中有63例(9.9%)检测到CBLmut。CBLmut在骨髓增生异常/骨髓增殖性肿瘤中的发生率高于骨髓增殖性肿瘤(51/328，15.5%vs.12/291，4.1%；P
We analyzed 636 patients with diverse myeloproliferative neoplasms or myelodysplastic/myeloproliferative neoplasms for mutations of the Casitas B-cell lymphoma gene (CBLmut) in exons 8 and 9 and performed correlations to other genetic alterations. CBLmut were detected in 63 of 636 (9.9%) of these selected patients. CBLmut were more frequent in myelodysplastic/myeloproliferative neoplasms than myeloproliferative neoplasms (51 of 328, 15.5% vs. 12 of 291, 4.1%; P