The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity
The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity
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DOI：
10.2174/092986609788923310
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发表时间：
2009-08-01
影响因子：
1.6
通讯作者：
Fontes, Marcos R. M.
中科院分区：
文献类型：
--
作者：
dos Santos, Juliana I.;Fernandes, Carlos A. H.;Fontes, Marcos R. M.
磷脂酶 A(2) 同源物存在于响尾蛇蛇的毒液中，其主要作用与诱导肌坏死有关。尽管已经对这些毒素进行了许多研究，但其作用机制仍不清楚。在此，我们回顾了这些毒素的重要方面，包括它们的正确生物组装以及天然替代 D49K 对于其催化失活的重要性。
Phospholipases A(2) homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.