Exercise and Cardiovascular Protection
Exercise and Cardiovascular Protection
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DOI：
10.1007/978-981-15-1792-1_14
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发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Gao, Feng
中科院分区：
文献类型：
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作者：
Li, Guohua;Li, Jia;Gao, Feng
越来越多的证据表明，运动训练不仅可以降低心血管疾病的风险，而且可以提供直接的内源性心血管保护。已经提出的运动诱导的心脏保护机制包括内在的心肌变化，如细胞溶质抗氧化能力增加和线粒体表型改变，肌因子介导的代谢和抗炎作用在心血管系统中，并通过器官间串扰对心血管系统的全身影响。运动对心脏的保护机制仍有许多有待阐明的问题。本章综述了运动引起的心血管系统的急性和慢性反应，运动训练和心肺适能在心血管疾病一级和二级预防中的流行病学证据，以及目前对运动引起的心血管保护作用机制的认识。
Accumulating evidence has demonstrated that exercise training not only reduces cardiovascular disease risk but also provides direct endogenous cardiovascular protection. The mechanisms that have been proposed to be responsible for exercise-induced cardioprotection include intrinsic myocardial changes such as increased cytosolic antioxidant capacity and altered mitochondrial phenotype, myokine-mediated metabolic and anti-inflammatory effects in the cardiovascular system, and systemic effects on the cardiovascular system via interorgan cross talk. There remains much to be elucidated in the mechanisms for exercise-afforded cardioprotection. This chapter reviews exercise-induced acute and chronic responses in cardiovascular system, the epidemiological evidence of exercise training and cardiorespiratory fitness in the primary and secondary prevention of cardiovascular diseases, and the current understanding of the mechanisms of exercise-induced cardiovascular protective effects.