Poststroke depression
Poststroke depression
复制标题
DOI：
10.1310/tsr1501-13
复制
发表时间：
2008-01-01
影响因子：
2.2
通讯作者：
Sharma, Aparna
中科院分区：
文献类型：
--
作者：
Dafer, Rima M.;Rao, Murah;Sharma, Aparna
神经心理症状可能是中风患者最常被忽视的并发症之一。抑郁症是中风的一种常见但往往未被认识到的神经心理后果，有生物学、心理行为和社会方面的因素。据报道，中风后抑郁的患病率在第一年内从20%到50%不等，在发病后的前6个月出现明显的高峰。报告患病率的差异在很大程度上取决于研究方法、诊断评估工具和中风发病后经过的时间。中风后抑郁的病因是复杂的；它可能由多种因素决定，包括病变位置、社会障碍和家庭支持。抑郁症阻碍了中风后的康复进程，并与功能结果受损、认知能力下降和死亡率增加有关。同样，抑郁症也与中风风险的增加有关。尽管中风后抑郁(PSD)的发病率很高，后遗症也很严重，但仍未被发现和治疗。早期诊断和成功的干预可能会改善临床结果，应该被认为是更好地治疗中风的关键。在这篇文章中，我们回顾了PSD的临床表现、流行病学、发病机制和后果，并总结了目前治疗干预的建议。
Neuropsychological symptoms are probably among the most commonly ignored complications in stroke patients. Depression is a common yet often unrecognized neuropsychological consequence of stroke, having biological, psycho-behavioral, and social dimensions. The reported prevalence of depression following a stroke varies from 20% to 50% within the first year, with an apparent peak within the first 6 months of onset event. The disparity of reported prevalence rates significantly depends on study methodology, diagnostic assessment tools, and time elapsed after stroke onset. The etiology of depression after a stroke is complex; it is likely determined by multiple factors, including lesion location, social handicap, and family support. Depression impedes rehabilitation progress following stroke and is associated with impaired functional outcome, cognitive decline, and increased mortality. Similarly, depression has been linked to increased risk of stroke occurrence. Despite high prevalence and serious sequels, poststroke depression (PSD) remains undetected and untreated. Early diagnosis and successful intervention may improve clinical outcome and should be considered a key for better stroke care. In this article, we review the clinical presentation, epidemiology, pathogenesis, and consequences of PSD and summarize current recommendations for therapeutic intervention.