Selection of unrelated compatible platelet donors by lymphocyte HL-A matching.
Selection of unrelated compatible platelet donors by lymphocyte HL-A matching.
复制标题
通过淋巴细胞 HL-A 匹配选择不相关的相容血小板供体。
DOI：
10.1056/nejm197304122881504
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
E. Henderson
中科院分区：
文献类型：
--
作者：
R. Yankee;K. S. Graff;R. Dowling;E. Henderson
血小板减少症患者输注来自随机供体的血小板无效时，来自HL-A相同同胞的血小板会有反应。然而，使用HL-A淋巴细胞分型选择无关相容血小板供体的有效性尚未得到充分证明。在这项研究中，3例对随机供体血小板无反应的患者输注了从选择的与HL-A匹配的无关人员中获得的血小板。20小时时测量的循环血小板中位应答（增量乘以体表面积/单位）分别为11.2、9.1和17.0（X 103），而非匹配血小板分别为0、0和2.2（X 103）。这些观察结果表明，在多次输血患者的同种异体免疫主要是由于HL-A抗原和淋巴细胞HL-A分型可用于选择无关兼容的血小板供体难治性患者。
Abstract Thrombocytopenic patients who are refractory to transfusions of platelets obtained from random donors will respond to platelets from HL-A-identical siblings. The efficacy of using HL-A lymphocyte typing to select unrelated compatible platelet donors, however, has not been well documented. In this study, three patients who were not responding to random donor platelets were transfused with platelets obtained from selected unrelated persons matched for HL-A. The median response in circulating platelets (increment times body-surface area per unit) measured at 20 hours was 11.2, 9.1 and 17.0 (X 103) as compared to 0, 0 and 2.2 (X 103), respectively, to nonmatched platelets. These observations indicate that alloimmunization in multi-transfused patients is primarily due to HL-A antigens and that lymphocyte HL-A typing can be used to select unrelated compatible platelet donors for refractory patients.