A highly effective cobalt catalyst for olefin aziridination with azides: Hydrogen bonding guided catalyst design
A highly effective cobalt catalyst for olefin aziridination with azides: Hydrogen bonding guided catalyst design
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DOI：
10.1021/ol800588p
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发表时间：
2008-05-15
期刊：
影响因子：
5.2
通讯作者：
Zhang, X. Peter
中科院分区：
文献类型：
--
作者：
Ruppel, Joshua V.;Jones, Jess E.;Zhang, X. Peter
[CO(P1)]是一种具有叠氮化物的高活性氮杂环化催化剂，它是基于金属-丁二烯中间体中潜在的氢键相互作用而设计的。[CO(P1)]能在温和的条件下与芳基磺酰叠氮化合物有效地催化各种芳香族烯烃反应，生成磺化氮杂环丙烷，产率很高。钴基系统具有与钴的相对较低的成本和芳基磺酰叠氮化合物的广泛可获得性相关的几个属性。此外，它还会产生稳定的氮素，作为唯一的副产品。
[Co(P1)], which was designed on the basis of potential hydrogen-bonding interactions in the metal-nitrene intermediate, is a highly active aziridination catalyst with azides. [Co(P1)] can effectively aziridinate various aromatic olefins with arylsulfonyl azides under mild conditions, forming sulfonylated aziridines in excellent yields. The Co-based system enjoys several attributes associated with the relatively low cost of cobalt and the wide accessibility of arylsulfonyl azides. Furthermore, it generates stable dinitrogen as the only byproduct.