The use of gold nanoparticle aggregation for DNA computing and logic-based biomolecular detection
The use of gold nanoparticle aggregation for DNA computing and logic-based biomolecular detection
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DOI：
10.1088/0957-4484/19/39/395103
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发表时间：
2008-10
期刊：
影响因子：
3.5
通讯作者：
In-Hee Lee;Kyungae Yang;Ji-hoon Lee;Ji-Yoon Park;Young-Gyu Chai;Jae-Hoon Lee;By Zhang
中科院分区：
文献类型：
--
作者：
In-Hee Lee;Kyungae Yang;Ji-hoon Lee;Ji-Yoon Park;Young-Gyu Chai;Jae-Hoon Lee;By Zhang
利用DNA分子作为物理计算材料已经引起了人们的极大兴趣，特别是在DNA计算领域。如果有有效的可视化方法，DNA也可用于生物系统的逻辑控制和分析。在这里，我们提出了一种快速，简单的可视化技术，显示的结果的DNA计算过程的基础上，由金纳米粒子聚集引起的比色变化，我们将其应用到基于逻辑的检测生物分子。我们的研究结果表明，它在基于DNA的逻辑计算和基于逻辑的生物分子检测的有效性。
The use of DNA molecules as a physical computational material has attracted much interest, especially in the area of DNA computing. DNAs are also useful for logical control and analysis of biological systems if efficient visualization methods are available. Here we present a quick and simple visualization technique that displays the results of the DNA computing process based on a colorimetric change induced by gold nanoparticle aggregation, and we apply it to the logic-based detection of biomolecules. Our results demonstrate its effectiveness in both DNA-based logical computation and logic-based biomolecular detection.