Therapeutic potential of valproic acid for retinitis pigmentosa
Therapeutic potential of valproic acid for retinitis pigmentosa
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DOI：
10.1136/bjo.2009.175356
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发表时间：
2011-01-01
影响因子：
4.1
通讯作者：
Kaushal, S.
中科院分区：
文献类型：
--
作者：
Clemson, C. M.;Tzekov, R.;Kaushal, S.
目的探讨丙戊酸（valproic acid，VPA）治疗视网膜色素变性（retinitis pigmentosa，RP）的有效性和安全性。使用数字化Goldmann动态视野描记法定义每只眼睛的视野（VF）。对VF面积进行对数转换，并计算相对于基线的VF损失/增益。使用Snellen视力表在20英尺（6.1 m）的距离处测量视力。结果治疗后，9只眼VF改善，2只眼VF下降，2只眼无变化，总体平均增加11%。假设在未治疗的情况下，VF区域出现典型损失，则VF增加具有统计学显著性（p
Background/aim To examine the efficacy and safety of valproic acid (VPA) in patients with retinitis pigmentosa (RP).Methods Thirteen eyes were examined before and after brief treatment (average 4 months) with VPA. Visual fields (VF) for each eye were defined using digitised Goldmann Kinetic Perimetry tracings. VF areas were log-transformed and VF loss/gain relative to baseline was calculated. Visual acuity was measured using a Snellen chart at a distance of 20 feet (6.1 m). Values were converted to the logarithm of the minimum angle of resolution (logMAR) score.Results Nine eyes had improved VF with treatment, two eyes had decreased VF and two eyes experienced no change, with an overall average increase of 11%. Assuming typical loss in VF area without treatment, this increase in VF was statistically significant (p