Reversal of two manifestations of dopamine receptor supersensitivity by administration of L-dopa.
Reversal of two manifestations of dopamine receptor supersensitivity by administration of L-dopa.
复制标题
通过施用左旋多巴逆转多巴胺受体超敏性的两种表现。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
H. Tosengarten
中科院分区：
文献类型：
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作者：
A. Friedhoff;K. Bonnet;H. Tosengarten
用多巴胺受体阻滞剂慢性处理的大鼠，纹状体~3H-多巴胺结合量和腺苷环化酶活性增加，这是受体超敏的表现。结合活性和腺苷环化酶活性的增加均可被慢性1-多巴处理逆转，可能是通过增加特定配体(多巴胺)的供应。对于涉及受体敏感性紊乱的情况，如迟发性运动障碍和胰岛素抵抗糖尿病，使用刻意的受体敏感性操纵可能是有用的。
Rats treated chronically with dopamine receptor blockers were found to have an increase in striatal 3H-dopamine binding and adenylate cyclase activity as manifestations of receptor supersensitivity. Both the increase in binding and in adenylate cyclase activity were reversed by chronic 1-dopa treatment, presumably by increasing the supply of specific ligand (dopamine). The use of deliberate receptor sensitivity manipulation may be useful as a treatment for conditions involving disturbances in receptor sensitivity such as tardive dyskinesia and insulin resistant diabetes.