Ectopic Ikaros Expression Positively Correlates With Lung Cancer Progression
Ectopic Ikaros Expression Positively Correlates With Lung Cancer Progression
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DOI：
10.1002/ar.22700
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发表时间：
2013-06
期刊：
影响因子：
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通讯作者：
Zhenfa Zhang;Zhao Xu;Xiaoyang Wang;Hao Wang;Z. Yao;Y. Mu;Zhenyi Ma;Zhe Liu
中科院分区：
文献类型：
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作者：
Zhenfa Zhang;Zhao Xu;Xiaoyang Wang;Hao Wang;Z. Yao;Y. Mu;Zhenyi Ma;Zhe Liu
由IKZF 1基因编码的Ikaros是一个关键的转录因子，其表达和利用在造血发育过程中动态改变。然而，在肺癌细胞系中控制IKZF 1基因转录的分子机制尚不清楚。在这里，我们展示了Ikaros在IIIA级肺癌患者队列中的作用，特别强调了其与临床结局和表达水平的关系。Ikaros表达水平与肺癌患者的预后呈正相关。我们还证明了Ikaros表达在一组肺癌细胞系中主要通过其启动子的去甲基化被异位激活。此外，功能获得实验表明，Ikaros在体外抑制肺癌细胞的迁移和侵袭。因此，我们的研究结果揭示了Ikaros如何作为谱系能力因子促进肺癌进展。Anat Rec，296：907-913，2013.© 2013 Wiley Periodicals，Inc.
Ikaros, encoded by the IKZF1 gene, is a pivotal transcription factor whose expression and utilization is dynamically altered during hematopoietic development. However, the molecular mechanisms controlling the transcription of the IKZF1 gene are unclear in lung cancer cell lines. Here we show the role of Ikaros in a cohort of grade IIIA lung cancer patients, with particular emphasis on its relationship with clinical outcomes and expression levels. The expression levels of Ikaros were positively correlated with the prognosis in the lung cancer patients. We also demonstrated that Ikaros expression is ectopically activated in a panel of lung cancer cell lines primarily through demethylation of its promoter. Moreover, gain‐of‐function experiments revealed that Ikaros inhibits migration and invasion of lung cancer cells in vitro. Our results thus shed light on how Ikaros can act as a lineage competency factor to facilitate lung cancer progression. Anat Rec, 296:907–913, 2013. © 2013 Wiley Periodicals, Inc.