Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2
Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2
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DOI：
10.1042/cs19980015
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发表时间：
1998-07-01
期刊：
影响因子：
6
通讯作者：
Leyssac, PP
中科院分区：
文献类型：
--
作者：
Geertsen, PF;von der Maase, H;Leyssac, PP
1. Renal haemodynamics, lithium and sodium clearance were measured in 14 patients treated with recombinant interleukin-2 for metastatic renal cell carcinoma.2. Patients were studied before and after 72 h of continuous intravenous infusion of recombinant interleukin-2 (18 x 10(6) i.u..24 h(-1).m(-2)) and 48 h post therapy. Cardiac output was measured by impedance cardiography. Effective renal plasma flow and glomerular filtration rate were determined by the renal clearances of I-131-hippuran and Tc-99m-diethylenetriaminepenta-acetic acid (DTPA) respectively. Renal clearance of lithium (C-Li) was used as an index of proximal tubular outflow.3. Treatment caused a transient decrease in mean arterial blood pressure and systemic vascular resistance, but cardiac output remained unchanged. Renal blood flow decreased and renal vascular resistance increased during and after treatment. Sodium clearance decreased from 1.10 (0.63/1.19) ml/min to 0.17 (0.18/0.32) ml/min (P = 0.003). Glomerular filtration rate remained unchanged, whereas the median C-Li decreased from 26 (17/32) ml/min to 17 (10/21) ml/min (P = 0.008). Calculated absolute proximal reabsorption rate of water increased from 63 (40/69) ml/min to 71 (47/82) ml/min (P = 0.04). The urinary excretion rate of thromboxane B-2, and the ratio between excretion rates of thromboxane B-2, and 6-keto-prostagtandin-F-1 alpha, increased by 98% (P = 0.022) and 175% (P = 0.022) respectively.4. The study suggests a specific recombinant interleukin-2-induced renal vasoconstrictor effect. Changes in renal prostaglandin synthesis may contribute to the decrease in renal blood flow. The lithium clearance data suggest that an increased proximal tubular reabsorption rate may contribute to the decreased sodium clearance during recombinant interleukin-2 treatment.
