Neurological manifestations of Niemann-Pick disease type C in cats.
Neurological manifestations of Niemann-Pick disease type C in cats.
复制标题
猫 C 型尼曼-皮克病的神经学表现。
DOI：
10.1111/j.1939-1676.1994.tb03208.x
复制
发表时间：
1994
影响因子：
2.6
通讯作者：
Wenger,DA
中科院分区：
文献类型：
--
作者：
Muñana,KR;Luttgen,PJ;Thrall,MA;Mitchell,TW;Wenger,DA
Seven Domestic shorthair cats with a lysosomal storage disorder analogous to human Niemann‐Pick disease type C, from a breeding colony were studied to characterize the neurological manifestations of this disorder. Affected cats were identified by means of liver biopsies at 4 to 6 weeks of age. Neurological examinations were performed at 2 week intervals from the onset of clinical signs. All cats displayed signs referrable to the cerebellum, with a subtle intention tremor noticed initially at 8 to 12 weeks of age; the disease was rapidly progressive. The tremor became more pronounced, menace response was lost, and severe dysmetria and ataxia developed. Three cats also had signs referrable to other areas of the central nervous system. Cats died or were euthanized between 12 and 43 weeks of age. Pathological findings included accumulation of substrate within neurons throughout the central nervous system, and axonal spheroid formation. The clinical and pathological findings in these cats are comparable to those in the human form of the disease.
DOI：
--
发表时间：
1979
期刊：
影响因子：
--
作者：
T. Holliday
通讯作者：
T. Holliday
DOI：
10.1016/0005-2760(80)90116-2
发表时间：
1980-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
PENTCHEV, PG;GAL, AE;BRADY, RO
通讯作者：
BRADY, RO
DOI：
--
发表时间：
1983
期刊：
Acta Universitatis Carolinae. Medica
影响因子：
--
作者：
M. Elleder;A. Jirásek
通讯作者：
A. Jirásek