AGC kinases in plant development and defense
AGC kinases in plant development and defense
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DOI：
10.4161/psb.6.7.15580
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发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
Oelmueller, Ralf
中科院分区：
文献类型：
--
作者：
Hirt, Heribert;Garcia, Ana V.;Oelmueller, Ralf
超过100，000篇出版物证明AGC激酶是哺乳动物系统中生长、代谢、增殖、细胞分裂、存活和凋亡的重要调节剂。(1)这些激酶的突变和/或失调有助于许多人类疾病的发病机制，包括癌症和糖尿病。虽然AGC激酶也存在于植物中，但对其功能知之甚少。我们证明AGC激酶氧化信号诱导1（OXI 1/AGC 2 -1）调节植物重要的发育过程和防御反应。对最近进展的总结也表明，我们才刚刚开始了解这种激酶途径在植物中的作用。
More than 100,000 publications demonstrate that AGC kinases are important regulators of growth, metabolism, proliferation, cell divison, survival and apoptosis in mammalian systems.(1) Mutation and/or dysregulation of these kinases contribute to the pathogenesis of many human diseases, including cancer and diabetes. Although AGC kinases are also present in plants, little is known about their functions. We demonstrated that the AGC kinase OXIDATIVE SIGNAL-INDUCIBLE1 (OXI1/AGC2-1) regulate important developmental processes and defense responses in plants. The summary of recent progress also demonstrates that we are only beginning to understand the role of this kinase pathway in plants.