COCHLEAR NUCLEUS, INFERIOR COLLICULUS, AND MEDIAL GENICULATE RESPONSES DURING THE BEHAVIORAL DETECTION OF THRESHOLD-LEVEL AUDITORY-STIMULI IN THE RABBIT
COCHLEAR NUCLEUS, INFERIOR COLLICULUS, AND MEDIAL GENICULATE RESPONSES DURING THE BEHAVIORAL DETECTION OF THRESHOLD-LEVEL AUDITORY-STIMULI IN THE RABBIT
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DOI：
10.1121/1.391736
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发表时间：
1985-01-01
影响因子：
2.4
通讯作者：
THOMPSON, RF
中科院分区：
文献类型：
--
作者：
KETTNER, RE;THOMPSON, RF
通过将白噪声条件刺激（CS）与角膜喷气非条件刺激（US）配对，使家兔对听觉刺激产生条件性行为反应。条件反应（CR）是瞬膜（NM）的运动。当受试者的反应超过90%的正确水平后，听觉刺激的强度使用阶梯程序降低到行为阈值。同时测量的神经单位活动和行为NM反应，然后在兔子进行行为阈值。实验完成后，将行为检测试验期间的神经单元反应与非检测试验期间的神经反应进行比较。神经单位的反应，以恒定的强度，白噪声刺激的行为阈值被很好地定义和基本相同的行为检测和非检测试验在腹侧耳蜗核，腹外侧部的中央核下丘，和腹侧部的内侧膝状体。听觉刺激可以被神经元“检测”而不被行为检测到，并且神经元的“决定”并不是在这些核团中做出的。从下丘中央核的背内侧部，下丘的中央周围核，以及不太常见的内侧膝状体的内侧部记录的反应也清楚地存在，几乎相同的听觉刺激的发病过程中，但有时一贯不同的检测和非检测条件下，在后半部分的听觉刺激。这些大脑区域似乎接受听觉和非听觉输入，并显示与检测行为高度相关的反应。
Rabbits were conditioned to respond behaviorally to auditory stimuli by pairing a white-noise conditioned stimulus (CS) with a corneal airpuff unconditioned stimulus (US). The conditioned response (CR) was movement of the nictitating membrane (NM). After the subjects were responding at better than the 90% correct level, the intensity of the auditory stimulus was reduced to behavioral threshold using a staircase procedure. Simultaneous measurements of neural unit activity and behavioral NM responses were then made in rabbits performing at behavioral threshold. After the experiment was completed neural unit responses during behavioral detection trials were compared to neural responses made during nondetection trials. Neural unit responses to a constant intensity, white-noise stimulus at behavioral threshold were well defined and essentially identical on behavioral detection and nondetection trials in the ventral cochlear nucleus, the ventrolateral division of the central nucleus of the inferior colliculus, and the ventral division of the medial geniculate body. An auditory stimulus can be neuronally "detected" without being behaviorally detected, and that the neural "decision" to respond behaviorally is not made in these nuclei. Responses recorded from the dorsomedial division of the central nucleus of the inferior colliculus, the pericentral nucleus of the inferior colliculus, and less commonly in the medial division of the medial geniculate body were also clearly present and nearly identical during the onset of the auditory stimulus, but were sometimes consistently different for detection and nondetection conditions during the latter part of the auditory stimulus. These brain regions appear to receive both auditory and nonauditory inputs, and show responses which are more highly correlated with detection behavior.