Improved dosimetry for targeted radionuclide therapy using nonrigid registration on sequential SPECT images
Improved dosimetry for targeted radionuclide therapy using nonrigid registration on sequential SPECT images
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DOI：
10.1118/1.4906242
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发表时间：
2015-02-01
期刊：
影响因子：
3.8
通讯作者：
Mok, Greta S. P.
中科院分区：
文献类型：
--
作者：
Ao, Edwin C. I.;Wu, Nien-Yun;Mok, Greta S. P.
Purpose: Voxel-level and patient-specific 3D dosimetry for targeted radionuclide therapy (TRT) typically involves serial nuclear medicine scans. Misalignment of the images can result in reduced dosimetric accuracy. Since the scans are typically performed over a period of several days, there will be patient movement between scans and possible nonrigid organ deformation. This work aims to implement and evaluate the use of nonrigid image registration on a series of quantitative SPECT (QSPECT) images for TRT dosimetry.Methods: A population of 4D extended cardiac torso phantoms, comprised of three In-111 Zevalin biokinetics models and three anatomical variations, was generated based on the patient data. The authors simulated QSPECT acquisitions at five time points. At each time point, individual organ and whole-body deformation between scans were modeled by translating/rotating organs and the body up to 5 degrees/voxels, keeping
