Recent advances in the ARID family: focusing on roles in human cancer.
Recent advances in the ARID family: focusing on roles in human cancer.
复制标题
ARID 家族的最新进展：关注人类癌症中的作用
DOI：
10.2147/ott.s57023
复制
发表时间：
2014
影响因子：
4
通讯作者：
Zhao H
中科院分区：
文献类型：
--
作者：
Lin C;Song W;Bi X;Zhao J;Huang Z;Li Z;Zhou J;Cai J;Zhao H
人类富含AT的相互作用结构域（ARID）家族包含7个亚家族和15个成员，其特征在于具有ARID。ARID家族成员具有调节转录的能力，并参与细胞分化和增殖。越来越多的证据表明，ARID家族成员参与癌症相关的信号通路，在肿瘤组织中高度突变或差异表达，并作为癌症预后或治疗结果的预测因素。本文就ARID家族在肿瘤中的作用的分子生物学和临床研究进行综述。这可能有助于我们从一个新的角度来理解癌症的发生和发展，并为癌症治疗提供潜在的靶点。
The human AT-rich interaction domain (ARID) family contains seven subfamilies and 15 members characterized by having an ARID. Members of the ARID family have the ability to regulate transcription and are involved in cell differentiation and proliferation. Accumulating evidence suggests that ARID family members are involved in cancer-related signaling pathways, highly mutated or differentially expressed in tumor tissues, and act as predictive factors for cancer prognosis or therapeutic outcome. Here we review the molecular biology and clinical studies concerned with the role played by the ARID family in cancer. This may contribute to our understanding of the initiation and progression of cancer from a novel point of view, as well as providing potential targets for cancer therapy.