Development of a common outcome data set for fall injury prevention trials: The prevention of falls network Europe consensus
Development of a common outcome data set for fall injury prevention trials: The prevention of falls network Europe consensus
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DOI：
10.1111/j.1532-5415.2005.53455.x
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发表时间：
2005-09-01
影响因子：
6.3
通讯作者：
Becker, C
中科院分区：
文献类型：
--
作者：
Lamb, SE;Jorstad-Stein, EC;Becker, C
预防与老年人福尔斯跌倒相关的伤害是世界上许多国家的公共卫生目标。虽然有充分的证据表明，干预措施，如多因素跌倒预防和个人规定的运动是有效的减少福尔斯，对严重伤害率的影响尚不清楚。1，2从历史上看，试验没有足够的把握度来检测损伤终点，并且试验之间病例定义的差异阻碍了荟萃分析。(1)预防跌倒的策略可能对导致受伤的福尔斯影响有限，或者对受伤风险较高的人群无效。预防福尔斯网络欧洲（ProFaNE）是一个合作项目，旨在通过卓越的研究和推广最佳实践（www.profane.eu.org）来减轻老年人跌倒伤害的负担。欧盟委员会资助该网络，该网络将世界各地的临床医生，公众和研究人员联系起来。其目的是确定在跌倒伤害预防知识的主要差距，并促进大规模的临床研究活动，包括临床试验，比较研究和前瞻性荟萃分析所需的合作。这项工作是在一个为期4年的方案中进行的。作为第一步，考虑为未来的试验或荟萃分析制定一套通用的结局定义和措施。
The prevention of injury associated with falls in older people is a public health target in many countries around the world. Although there is good evidence that interventions such as multifactorial fall prevention and individually prescribed exercise are effective in reducing falls, the effect on serious injury rates is unclear. 1,2 Historically, trials have not been adequately powered to detect injury endpoints, and variations in case definition across trials have hindered meta-analysis.(1) It is possible that fall-prevention strategies have limited effect on falls that result in injuries or are ineffective in populations who are at a higher risk of injury. Further research is required to determine whether fall-prevention interventions can reduce serious injuries.Prevention of Falls Network Europe (ProFaNE) is a collaborative project to reduce the burden of fall injury in older people through excellence in research and promotion of best practice (www.profane.eu.org). The European Commission funds the network, which links clinicians, members of the public, and researchers worldwide. The aims are to identify major gaps in knowledge in fall injury prevention and to facilitate the collaboration necessary for large-scale clinical research activity, including clinical trials, comparative research, and prospective meta-analysis. Work is being undertaken in a 4-year program. As a first step, the development of a common set of outcome definitions and measures for future trials or meta-analysis was considered.