Wine Consumption and Other Dietary Variables in Males Under 60 Before and After Acute Myocardial Infarction
Wine Consumption and Other Dietary Variables in Males Under 60 Before and After Acute Myocardial Infarction
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60 岁以下男性急性心肌梗死前后的葡萄酒消费量和其他饮食变量
DOI：
10.1177/000331979604700806
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发表时间：
1996
期刊：
影响因子：
2.8
通讯作者：
K. Zwinderman
中科院分区：
文献类型：
--
作者：
T. Cleophas;Ellen Tuinenberg;J. van der Meulen;K. Zwinderman
在法国，尽管动物脂肪摄入量很高，但心脏病死亡人数很少。法国和意大利是世界上酒精摄入量最高的国家。显然，在这些国家，冠心病（CHD）和酒精摄入量之间存在负相关。虽然在过去的十年中，一些大规模的人群研究已经证实了酒精对冠心病的有益影响，这些研究可能并不敏感，以控制所有的混杂变量。到目前为止，还没有人探讨过法国人可能受到低生活压力保护的可能性。在1993年，我们进行了一项病例对照研究（n = 118），以检查一组荷兰男性60岁以下，急性心肌梗死（MI）之前和之后的心理变量。在调整总胆固醇、血压和吸烟后，许多心理因素似乎与MI风险增加独立相关。在本研究中，对同一组患者进行了不同类型酒精饮料、咖啡、糖、高脂肪饮食和蔬菜的消费评估。在单变量分析中，患者似乎喝了更多的红酒（比值比[OR] 0.2，P = 0.03），控制了更多的烈酒（OR 4.0，P = 0.005）。在调整了总胆固醇、血压、吸烟以及独立的心理因素后，红酒失去了其显著性（OR 0.4，P = 0.17），而烈酒的OR甚至上升（OR 6.0，P = 0.01）。葡萄酒的有益效果可能是相对较低水平的生活压力的表达。酒精本身不是保护性的，而是MI的一个强风险因素。
In France there are few cardiac deaths in spite of high animal fat intake. France and Italy have the highest overall intake of alcohol in the world. Obviously, there is an inverse association between coronary heart disease (CHD) and alcohol intake in these countries. Although in the past decade several-large scale population studies have confirmed the beneficial effect of alcohol on CHD, these studies may not have been sensitive to control all the confounding variables. No one so far has explored the possibility that the French may be protected by their low level of life stress. In 1993 we conducted a case-control study (n = 118) to examine psychological variables in a group of Dutch males under sixty years of age, before and after acute myocardial infarction (MI). After adjustment for total cholesterol, blood pressure, and smoking, a number of psychological factors appeared to be independently associated with an increased risk of MI. For the present study the same group of patients was assessed for consumption of different types of alcoholic beverages, coffee, sugar, high-fat diet, and vegetables. In the univariate analysis patients appeared to have consumed more red wine (odds ratio [OR] 0.2, P = 0.03) and controls more spirits (OR 4.0, P = 0.005). After adjustment for total cholesterol, blood pressure, and smoking as well as the independent psycholog ical factors, red wine lost its significance (OR 0.4, P = 0.17) whereas the OR for spirits even rose (OR 6.0, P = 0.01). The beneficial effect of wine may be an expression of a relatively low level of life stress. Alcohol itself is not protective but rather a strong risk factor of MI.