IMMUNOCYTOCHEMICAL STUDY OF THE GASTROENTEROPANCREATIC ENDOCRINE-CELLS OF THE SHEEP
IMMUNOCYTOCHEMICAL STUDY OF THE GASTROENTEROPANCREATIC ENDOCRINE-CELLS OF THE SHEEP
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DOI：
10.1159/000145840
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
YAMASHITA, T
中科院分区：
文献类型：
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作者：
CALINGASAN, NY;KITAMURA, N;YAMASHITA, T
应用免疫细胞化学方法对绵羊胃肠胰腺（GEP）内分泌细胞进行了研究，并测定了其分布和频率。共发现11种内分泌细胞。在皱胃中，生长抑素，胃泌素，胰高血糖素和香菇免疫反应细胞检测到幽门区的频率最高。在小肠中，生长抑素-，胃泌素-，CCK[胆囊收缩素]-，胃动素-，神经降压素-，分泌素-，P物质-，胰高血糖素-，胰高血糖素-和BPP [牛胰多肽]-免疫反应细胞被发现，并在十二指肠最多，除了神经降压素-，胰高血糖素-和胰高血糖素-免疫反应细胞，这是更集中在回肠。在大肠中，生长抑素，P物质，胰高血糖素，胰高血糖素和BPP免疫反应细胞定位与最后3种细胞类型更集中在直肠。在胰腺中，生长抑素-，胰高血糖素-，glicentin-，BPP-和胰岛素免疫反应细胞占主导地位的胰岛内，也分散在外分泌部分，很少检测到导管上皮细胞。本文还讨论了绵羊GEP内分泌细胞的分布和频率与单胃动物GEP内分泌细胞的差异。
The gastroenteropancreatic (GEP) endocrine cells of the sheep were studied immunocytochemically, and their distribution and frequency were determined. Eleven types of endocrine cells were revealed. In the abomasum, somatostatin-, gastrin-, glucagon- and glicentin-immunoreactive cells were detected with the highest frequency in the pyloric region. In the small intestine, somatostatin-, gastrin-, CCK[cholecystokinin]-, motilin-, neurotensin-, secretin-, substance P-, glucagon-, glicentin- and BPP [bovine pancreatic polypeptide]-immunoreactive cells were found, and were most numerous in the duodenum except in neurotensin-, glucagon- and glicentin-immunoreactive cells which were more concentrated in the ileum. In the large intestine, somatostatin-, substance P-, glucagon-, glicentin- and BPP-immunoreactive cells were localized with the last 3 cell types being more concentrated in the rectum. In the pancreas, somatostatin-, glucagon-, glicentin-, BPP- and insulin-immunoreactive cells predominated within the islets, and were also scattered in the exocrine portion and rarely detected in duct epithelial cells. The differences between the distribution and frequency of the GEP endocrine cells of the sheep and those of monogastric species are discussed.