Acute toxicity and behavioral effects of chlorpyrifos, permethrin, phenol, strychnine, and 2,4‐dinitrophenol to 30‐day‐old Japanese medaka (Oryzias latipes)
Acute toxicity and behavioral effects of chlorpyrifos, permethrin, phenol, strychnine, and 2,4‐dinitrophenol to 30‐day‐old Japanese medaka (Oryzias latipes)
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毒死蜱、氯菊酯、苯酚、马钱子碱和 2,4-二硝基苯酚对 30 日龄日本青鳉 (Oryzias latipes) 的急性毒性和行为影响
DOI：
10.1002/etc.5620160414
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发表时间：
1997
影响因子：
4.1
通讯作者：
J. Coats
中科院分区：
文献类型：
--
作者：
Patricia J. Rice;C. Drewes;Theresa M. Klubertanz;S. Bradbury;J. Coats
在实验室研究中评估了五种具有不同作用模式的化学物质，以确定它们对30天龄日本水豚（Oryzias latipes）的急性毒性（48‐h中位致死浓度[LC50]）和行为影响。其毒性排序为氯菊酯b>毒死蜱b> 2,4 -二硝基苯酚（2,4 - DNP） b>士的宁b>苯酚。48 h lc50差异显著，范围为0.011 ~ 24.1 mg/L。此外，毒死蜱和氯菊酯在幼蚊组织中有蓄积。观察五种行为/形态反应，包括平衡、一般活动、惊吓反应和形态（如出血和畸形）的变化，作为亚致死毒性的指标。除了2,4 - DNP外，每种化学物质都会引起不同的行为或一系列行为反应。行为毒理学生物测定在比较和预测新的或未知的毒物对该鱼类的作用方式方面可能是有价值的。
Five chemicals with different modes of action were evaluated in laboratory studies to determine their acute toxicity (48‐h median lethal concentration [LC50]) and behavioral effects on 30‐d‐old Japanese medaka (Oryzias latipes). The order of toxicity for these xenobiotics was permethrin > chlorpyrifos > 2,4‐dinitrophenol (2,4‐DNP) > strychnine > phenol. The 48‐h LC50s were significantly different and ranged from 0.011 to 24.1 mg/L. In addition, chlorpyrifos and permethrin accumulated in the tissues of juvenile O. latipes. Observations of five behavioral/morphological responses, including changes in equilibrium, general activity, startle response, and morphology (e.g., hemorrhage and deformities) were used as indicators of sublethal toxicity. Each chemical, with the exception of 2,4‐DNP, elicited a distinct behavior or set of behavioral responses. The behavioral toxicology bioassay may be valuable in comparing and predicting the mode of action of new or unknown toxicants in this species of fish.