Intramuscular temperature modulates glutamate-evoked masseter muscle pain intensity in humans.
Intramuscular temperature modulates glutamate-evoked masseter muscle pain intensity in humans.
复制标题
肌内温度调节人类谷氨酸引起的咬肌疼痛强度。
DOI：
10.11607/ofph.1332
复制
发表时间：
2015
影响因子：
2.5
通讯作者：
P. Svensson
中科院分区：
文献类型：
--
作者：
Hitoshi Sato;E. Castrillon;B. Cairns;K. Bendixen;Kelun Wang;T. Nakagawa;K. Wajima;P. Svensson
目标管理系统
确定谷氨酸引起的下颌肌肉疼痛是否会因注射溶液的温度而改变。
方法
十六名健康志愿者参与并接受了热（48°C）、中性（36°C）或冷（3°C）谷氨酸溶液（0.5 mL）或等渗盐水的咬肌注射。使用电子视觉模拟量表（eVAS）评估疼痛强度。还测量了不愉快和温度感知、疼痛绘制区域和压痛阈值 (PPT) 的数字评定量表 (NRS) 分数。参与者填写了麦吉尔疼痛问卷（MPQ）。使用双向或三向重复测量方差分析进行数据分析。
结果
与注射中性谷氨酸溶液相比，注射热谷氨酸和冷谷氨酸溶液的峰值疼痛强度分别显着增加和降低。注射热谷氨酸时谷氨酸引起的疼痛持续时间明显长于注射冷谷氨酸时。当注射等渗盐水时，没有观察到温度对疼痛强度的显着影响。未检测到溶液温度对不愉快感、热感知、冷感知、疼痛绘图区域或 PPT 的影响。与注射中性溶液和热溶液相比，MPQ 中更多地使用“麻木”术语来描述冷溶液的注射。
结论
注射溶液的温度显着改变了谷氨酸引起的下颌肌肉疼痛。尽管颌部肌肉的温度感知较差，但当肌肉组织温度升高时疼痛强度会增加。
AIMS
To determine whether glutamate-evoked jaw muscle pain is altered by the temperature of the solution injected.
METHODS
Sixteen healthy volunteers participated and received injections of hot (48°C), neutral (36°C), or cold (3°C) solutions (0.5 mL) of glutamate or isotonic saline into the masseter muscle. Pain intensity was assessed with an electronic visual analog scale (eVAS). Numeric rating scale (NRS) scores of unpleasantness and temperature perception, pain-drawing areas, and pressure pain thresholds (PPTs) were also measured. Participants filled out the McGill Pain Questionnaire (MPQ). Two-way or three-way repeated measures ANOVA were used for data analyses.
RESULTS
Injection of hot glutamate and cold glutamate solutions significantly increased and decreased, respectively, the peak pain intensity compared with injection of neutral glutamate solution. The duration of glutamate-evoked pain was significantly longer when hot glutamate was injected than when cold glutamate was injected. No significant effect of temperature on pain intensity was observed when isotonic saline was injected. No effect of solution temperature was detected on unpleasantness, heat perception, cold perception, area of pain drawings, or PPTs. There was a significantly greater use of the "numb" term in the MPQ to describe the injection of cold solutions compared to the injection of both neutral and hot solutions.
CONCLUSION
Glutamate-evoked jaw muscle pain was significantly altered by the temperature of the injection solution. Although temperature perception in the jaw muscle is poor, pain intensity is increased when the muscle tissue temperature is elevated.