Hydrophilic hybrid IPNs of segmented polyurethanes and copolymers of vinylpyrrolidone for applications in medicine
Hydrophilic hybrid IPNs of segmented polyurethanes and copolymers of vinylpyrrolidone for applications in medicine
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DOI：
10.1016/s0142-9612(00)00381-1
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发表时间：
2001-07-01
期刊：
影响因子：
14
通讯作者：
San Román, JS
中科院分区：
文献类型：
--
作者：
Abraham, GA;de Queiroz, AAA;San Román, JS
描述了由嵌段聚脲、Biospan（TM）（BS）和乙烯基吡咯烷酮-二甲基丙烯酰胺（VP-DMAm）共聚物组成的热塑性表观互穿聚合物网络（T-IPN）的制备和生物相容性。通过体外实验研究了材料与血液的生物学相互作用。加入VP-DMAm共聚物与BS形成的T-IPN显著增加了平衡吸水率和水扩散系数。研究了蛋白质吸附、血小板粘附、血栓形成和因子XII活化。对BS/VP-DMAm T-IPN表面的蛋白质吸附的研究表明，具有较高VP含量的含有VP-DMAm共聚物的嵌段聚氨酯（BS）吸附比纤维蛋白原和γ-球蛋白更多的白蛋白。当具有高VP含量的VP-DMAm共聚物作为T-IPN掺入BS中时，相对于嵌段聚氨酯，血小板粘附、血栓形成和因子XII活化被有效地抑制。(C)2001年由Elsevier Science Ltd.出版
The preparation and biocompatibility properties of thermoplastic apparent interpenetrating polymer networks (T-IPNs) of a segmented polyurethaneurea, Biospan (TM) (BS), and vinyipyrrolidone-dimethylacrylamide (VP-DMAm) copolymers, are described. The biological interaction between the obtained materials and blood was studied by in vitro methods. The addition of the VP-DMAm copolymers to form T-IPNs with BS substantially increased the equilibrium water uptake and water diffusion coefficients. Investigation of the proteins adsorption, platelet adhesion, thrombus formation and factor XII activation is presented. investigations of the proteins adsorption of the BS/VP-DMAm T-IPNs surfaces show that the segmented polyurethane (BS) containing VP-DMAm copolymers with higher VP content adsorb more albumin than fibrinogen and gamma -globulin. The platelets adhesion, thrombus formation and factor XII activation are effectively suppressed with respect to the segmented polyurethane when VP-DMAm copolymers with high VP contents are incorporated into BS as T-IPNs. (C) 2001 Published by Elsevier Science Ltd.