The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology.
The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology.
复制标题
Cdkn1A 相互作用锌指蛋白 1 (CIZ1) 在 DNA 复制和病理生理学中的作用（综述）
DOI：
10.3390/ijms17020212
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发表时间：
2016-02-05
影响因子：
5.6
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Liu Q;Niu N;Wada Y;Liu J
Cdkn1A 相互作用锌指蛋白 1 (CIZ1) 首次在酵母 2 杂交系统中被发现，该系统寻找 CDK2 抑制剂 p21Cip1/Waf1 的相互作用蛋白。 Ciz1 还结合 CDK2、细胞周期蛋白 A、细胞周期蛋白 E、CDC6、PCNA、TCF4 和雌激素受体-α。最近的研究揭示了 CIZ1 在 DNA 复制、细胞增殖和分化中的多种生物学功能。此外，CIZ1 mRNA的剪接变异与多种癌症和阿尔茨海默病有关，CIZ1基因的突变会导致颈肌张力障碍。 CIZ1 表达在癌症和类风湿性关节炎中增加。本文将总结CIZ1在这些生理和病理过程中的生物学功能和分子机制。
Cdkn1A-interacting zinc finger protein 1 (CIZ1) was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21Cip1/Waf1. Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-α. Recent studies reveal numerous biological functions of CIZ1 in DNA replication, cell proliferation, and differentiation. In addition, splicing variants of CIZ1 mRNA is associated with a variety of cancers and Alzheimer’s disease, and mutations of the CIZ1 gene lead to cervical dystonia. CIZ1 expression is increased in cancers and rheumatoid arthritis. In this review, we will summarize the biological functions and molecular mechanisms of CIZ1 in these physiological and pathological processes.