Distribution of Nonperfusion Area on Ultra-widefield Fluorescein Angiography in Eyes With Diabetic Macular Edema: DAVE Study
Distribution of Nonperfusion Area on Ultra-widefield Fluorescein Angiography in Eyes With Diabetic Macular Edema: DAVE Study
复制标题
DOI：
10.1016/j.ajo.2017.05.024
复制
发表时间：
2017-08-01
影响因子：
4.2
通讯作者：
Sadda, Srinivas R.
中科院分区：
文献类型：
--
作者：
Fan, Wenying;Wang, Kang;Sadda, Srinivas R.
目的：探讨糖尿病黄斑水肿(DME)患者眼内无灌注区(NPA)的分布及其与DME严重程度的关系。设计：前瞻性观察病例系列。方法：参加Dave研究(NCT01552408)的初治DME患者29例(40眼)。超宽视野荧光素血管成像图像被发送到Doheny图像阅读中心，在那里它们被蒙太奇和使用赤平投影校正，以调整外围失真。两名经验丰富的独立/蒙面认证评分员手动分割NPA和总可见视网膜面积(TRA)，并以平方毫米(mm(2))计算NPA和TRA。计算缺血指数(ISI)。结果：40只未接受治疗的DME患者(平均年龄55.8岁)视力(VA)(平均59.6EDTRS字母)与黄斑中心厚度(CMT)(平均536.9µm，R=-0.418，P=0.008)和黄斑体积(MV)(平均11.9 mm(3)，R=-0.449，P=0.004)呈正相关。不同视网膜带之间的NPA和ISI差异有统计学意义(NPA：P<；.001；ISI：P=.005)。中央周边的NPA和ISI与CMT呈负相关(NPA：P=0.04；ISI：P=0.02)。然而，整个视网膜的整体NPA和ISI与CMT或MV无关(P>；0.05)。结论：DME患者的ISI随着距离中心凹的增加而增加。DME的严重程度似乎与全局NPA和ISI无关。(C)2017 Elsevier Inc.版权所有。
PURPOSE: To explore the distribution of nonperfusion area (NPA) in eyes with diabetic macular edema (DME) and its relationship with the severity of DME.DESIGN: Prospective, observational case series.METHODS: Forty eyes of 29 patients with treatment naive DME who participated in the DAVE study (NCT01552408) were included. Ultra-widefield fluorescein angiography images were sent to the Doheny Image Reading Center, where they were montaged and corrected using stereographic projection to adjust for peripheral distortion. Two experienced, independent/masked certified graders manually segmented the NPA and the total.visible retinal area (TRA), and computed the NPA and TRA in square millimeters (mm(2)). The ischemic index (ISI) was calculated. The distributions of NPA and ISI within different retinal zones were correlated with the severity of DME.RESULTS: In 40 eyes with treatment-naive DME (mean age, 55.8 years) visual acuity (VA) (mean 59.6 EDTRS letters) was correlated with central macular thickness (CMT) (mean 536.9 mu m, R = -0.418, P = .008) and macular volume (MV) (mean 11.9 mm(3), R = -0.449, P =.004). The NPA and ISI among the different retinal zones were significantly different (NPA: P < .001; ISI: P = .005). The NPA and ISI in the midperiphery were negatively 'associated with CMT (NPA: P = .04; ISI: P = .02). However, the global NPA and ISI for the entire retina were not associated with CMT or MV (P > .05).CONCLUSION: In eyes with DME, the ISI increases with increasing distance from the fovea. The severity of DME does not appear to correlate with global NPA and ISI. (C) 2017 Elsevier Inc. All rights reserved.