A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.
A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.
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DOI：
10.1039/c4cc03731f
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发表时间：
2014-10-09
期刊：
影响因子：
--
通讯作者：
Ran C
中科院分区：
文献类型：
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作者：
Zhang X;Tian Y;Yuan P;Li Y;Yaseen MA;Grutzendler J;Moore A;Ran C
在本报告中，我们设计了一种高亮度的双功能姜黄素类似物CRANAD-28。体内双光子成像表明，CRANAD-28可穿透血脑屏障（BBB）并标记斑块和脑淀粉样血管病（CAA）。我们还证明了这种成像探针可以抑制由铜或自然条件诱导的淀粉样蛋白β的交联。
In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label plaques and cerebral amyloid angiopathy (CAAs). We also demonstrated that this imaging probe could inhibit the crosslinking of amyloid beta induced either by copper or by natural conditions.