Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
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DOI：
10.1079/bjn20041225
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发表时间：
2004-09-01
影响因子：
3.6
通讯作者：
Delzenne, NM
中科院分区：
文献类型：
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作者：
Cani, PD;Dewever, C;Delzenne, NM
本研究验证的假设是，饮食中的果聚糖能够调节参与控制食物摄入量的胃肠道多肽，即胰高血糖素样肽(GLP)-1(7-36)酰胺和Ghrelin。给雄性Wistar大鼠喂以标准饲料(对照组)或添加100g不同聚合度果聚糖(低聚果糖、增效剂1或长链菊粉)/kg的相同饲料3周后，禁食8h后取材。在整个实验过程中，膳食能量摄入量显著低于对照组(P
The hypothesis tested in the present study is that dietary fructans are able to modulate gastrointestinal peptides involved in the control of food intake, namely glucagon-like peptide (GLP)-1 (7-36) amide and ghrelin. After 3 weeks of treatment with a standard diet (control) or 14 the same diet enriched with 100 g fructans varying in their degrees of polymerization (oligofructose (OFS), Synergy 1 (Syn) or long chain inulin)/kg, male Wistar rats were deprived of food for 8 h before sample collection. Dietary energy intake throughout the experiment was significantly lower (P