INSECT EPIDERMIS - DISTURBANCE OF SUPRACELLULAR TISSUE POLARITY DOES NOT PREVENT THE EXPRESSION OF CELL POLARITY
INSECT EPIDERMIS - DISTURBANCE OF SUPRACELLULAR TISSUE POLARITY DOES NOT PREVENT THE EXPRESSION OF CELL POLARITY
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DOI：
10.1007/bf00395951
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发表时间：
1987-01-01
期刊：
影响因子：
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通讯作者：
NUBLERJUNG, K
中科院分区：
文献类型：
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作者：
NUBLERJUNG, K
昆虫体壁在极化角质层结构的均匀取向中显示平面组织极性。例如，在体节中，由组成表皮细胞产生的齿状突起和刚毛指向后方。秋水仙素可以消除这种统一的方向，同时仍然允许单个细胞形成定向的表皮结构，从而表达细胞极性。这表明，在一个片中的单个细胞可以建立平面极性，而无需参考整个表皮中的某种隐蔽的细胞外线索（如形态发生梯度）。结果还表明，秋水仙素干扰-直接或间接-与参与排列的极性轴的单个细胞到一个共同的方向，从而产生超细胞或组织极性的机制。
The insect integument displays planar tissue polarity in the uniform orientation of polarized cuticular structures. In a body segment, for example, the denticles and bristles produced by the constituent epidermal cells point posteriorly. Colchicine can abolish this uniform orientation while still allowing individual cells to form orientated cuticular structures and thereby to express cell polarity. This suggests that an individual cell in a sheet can establish planar polarity without reference to some kind of covert supracellular cue (such as a morphogen gradient) in the epidermis as a whole. The results also indicate that colchicine interferes — directly or indirectly — with the mechanisms involved in aligning the polarity axes of individual cells into a common orientation, thereby generating supracellular or tissue polarity.