A Large-Scale Circuit Mechanism for Hierarchical Dynamical Processing in the Primate Cortex.
A Large-Scale Circuit Mechanism for Hierarchical Dynamical Processing in the Primate Cortex.
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DOI：
10.1016/j.neuron.2015.09.008
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发表时间：
2015-10-21
期刊：
影响因子：
16.2
通讯作者：
Wang XJ
中科院分区：
文献类型：
--
作者：
Chaudhuri R;Knoblauch K;Gariel MA;Kennedy H;Wang XJ
我们建立了猕猴新皮层的大规模动态模型，该模型基于最近从通道追踪实验中获得的定向和加权连接数据，并考虑了区域间的异质性。从这个系统中自然产生了时间尺度的层次结构：感觉区域对输入表现出短暂的、短暂的反应（适合于感觉处理），而联想区域随着时间的推移整合输入并表现出持续的活动（适合于决策和工作记忆）。该模型显示了多个时间层次，正如对视觉刺激和体感刺激的对比反应所证明的那样。此外，较慢的前额叶和颞叶区域对整体大脑动态有不成比例的影响。这些发现建立了沿皮层层次逐渐扩大的“颞接受窗”的回路机制，表明决策过程中的时间整合从局部回路延伸到大回路，并应通过考虑区域间异质性，促使对功能连通性分析（通过fMRI或EEG/MEG测量）的重新评估。
We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, transient responses to input (appropriate for sensory processing), whereas association areas integrate inputs over time and exhibit persistent activity (suitable for decision-making and working memory). The model displays multiple temporal hierarchies, as evidenced by contrasting responses to visual versus somatosensory stimulation. Moreover, slower prefrontal and temporal areas have a disproportionate impact on global brain dynamics. These findings establish a circuit mechanism for “temporal receptive windows” that are progressively enlarged along the cortical hierarchy, suggest an extension of time integration in decision-making from local to large circuits, and should prompt a re-evaluation of the analysis of functional connectivity (measured by fMRI or EEG/MEG) by taking into account inter-areal heterogeneity.