Immune responsiveness of splenocytes after chronic daily melatonin administration in male syrian hamsters
Immune responsiveness of splenocytes after chronic daily melatonin administration in male syrian hamsters
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DOI：
10.1016/s0165-2478(97)00039-4
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发表时间：
1997-07-01
影响因子：
4.4
通讯作者：
McMurray, DN
中科院分区：
文献类型：
--
作者：
Champney, TH;Prado, J;McMurray, DN
免疫系统和松果体激素，褪黑激素之间的相互关系，最近已被探讨。本研究调查了每日注射褪黑激素对雄性叙利亚仓鼠生殖和脾脏功能的影响。每天注射褪黑激素8-10周后，睾丸重量和血清睾酮水平下降。褪黑激素处理的仓鼠表现出增加脾淋巴细胞增殖反应的多克隆T细胞有丝分裂原（刀豆球蛋白A（Con-A）），但与多克隆B细胞有丝分裂原（脂多糖）刺激后增殖减少。似乎每天注射褪黑激素在雄性仓鼠中增加T细胞介导的免疫能力，同时降低抗体介导的免疫潜力。这些数据表明，慢性，每天褪黑激素改变免疫系统的反应，在仓鼠的细胞和体液反应的平衡。(C)1997年Elsevier Science B.V.
The interrelationships between the immune system and the pineal hormone, melatonin, have been explored recently. The present studies investigated the effects of daily melatonin injections on reproductive and spleen function in male Syrian hamsters. Testes weights and serum testosterone levels were depressed after 8-10 weeks of daily melatonin injections. Melatonin-treated hamsters exhibited increased splenic lymphoproliferative responses to a polyclonal T-cell mitogen (concanavalin A (Con-A)), but decreased proliferation following stimulation with a polyclonal B-cell mitogen (lipopolysaccharide). It appears that daily melatonin injections in male hamsters increase the T-cell-mediated immune capacity while reducing the antibody-mediated immune potential. These data suggest that chronic, daily melatonin alters immune system responsiveness in hamsters by shifting the balance of cellular and humoral reactivity. (C) 1997 Elsevier Science B.V.