Monitoring the microenvironment and microvasculature of primary pancreatic tumor under photothermal-induced immunotherapy by optical coherence tomography (Conference Presentation)
Monitoring the microenvironment and microvasculature of primary pancreatic tumor under photothermal-induced immunotherapy by optical coherence tomography (Conference Presentation)
复制标题
通过光学相干断层扫描监测光热诱导免疫治疗下原发性胰腺肿瘤的微环境和微血管（会议演讲）
DOI：
10.1117/12.2651195
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tang, Qinggong
中科院分区：
文献类型：
--
作者：
Yan, Feng;Valerio, Trisha I.;Wang, Chen;Chen, Wei R.;Tang, Qinggong
我们利用光学相干断层扫描（OCT）监测光热治疗诱导的免疫治疗前后胰腺肿瘤微环境和微血管的纵向进展。将原发性胰腺肿瘤植入小鼠腿上并通过光热疗法诱导的免疫疗法治疗，每三天观察一次，持续36天。对基于强度的OCT结构、均匀性、纹理、固有光学衰减对比度和血管结构进行检测和分析。我们的研究结果表明，光热诱导的免疫治疗可以引起原发性胰腺肿瘤的微环境和微血管内的组织结构和血管分布的显着变化。
We utilized optical coherence tomography (OCT) to monitor the longitudinal progression of the microenvironment and microvasculature of pancreatic tumors before and after the photothermal therapy-induced immunotherapy in vivo. The primary pancreatic tumors implanted on mouse legs and treated via the photothermal therapy-induced immunotherapy were observed every three days for 36 days. The intensity-based OCT structure, uniformity, texture, intrinsic optical attenuation contrast, and vascular structures were detected and analyzed. Our result demonstrated that the photothermal-induced immunotherapy could cause significant changes in the distribution of the tissue structure and vasculature within the microenvironment and microvasculature of the primary pancreatic tumors.