Angiotensin II increases cardiac protein synthesis in adult rat heart.
Angiotensin II increases cardiac protein synthesis in adult rat heart.
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血管紧张素 II 增加成年大鼠心脏中的心脏蛋白质合成。
DOI：
10.1152/ajpheart.1993.265.1.h238
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Scheuer,J
中科院分区：
文献类型：
--
作者：
Geenen,DL;Malhotra,A;Scheuer,J
本研究考察了血管紧张素II （ANG II）对先前在失神经大鼠心脏中观察到的心肌萎缩的直接作用。移植心脏的大鼠输注生理盐水（1微升/小时）或溶解于生理盐水（3微克。kg-1.h-1）的angii亚压剂量，持续1周。盐水输注组和angii输注组移植心脏左室（LV）质量分别降低29%和18% （P < 0.05）。移植心脏总左室蛋白合成1.4 +/- 0.1 mg.LV-1。与2.2 +/- 0.2 mg.LV-1相比。ANG II组在第1天（P < 0.05）。心率和颈动脉收缩压不受ANG II输注的影响，在该模型中正常观察到的α -肌球蛋白重链的减少在两组之间没有变化（61 +/- 3和66 +/- 1%，生理盐水与ANG II）。这些数据表明，ANG II增加了成人心脏的总心脏蛋白合成，导致心脏萎缩的衰减。ANG II未能阻止从α -肌球蛋白重链向β -肌球蛋白重链的转变可能与其对心率缺乏影响有关，因为其他影响肌球蛋白同工酶分布的干预措施也会增加心率。
This study examined the direct effect of angiotensin II (ANG II) on cardiac muscle atrophy previously observed in the denervated rat heart. Rats with transplanted hearts were infused with normal saline (1 microliter/h) or a subpressor dose of ANG II dissolved in saline (3 micrograms.kg-1.h-1) for 1 wk. Left ventricular (LV) mass of transplanted hearts decreased by 29 and 18% in the saline-infused and ANG II-infused groups, respectively (P < 0.05). Total LV protein synthesis of the transplanted heart was 1.4 +/- 0.1 mg.LV-1.day-1 in the saline compared with 2.2 +/- 0.2 mg.LV-1.day-1 in the ANG II (P < 0.05) group. Heart rate and carotid systolic arterial pressures were not affected by ANG II infusion, and the decrease in alpha-myosin heavy chain normally observed in this model was unchanged between the two groups (61 +/- 3 and 66 +/- 1%, saline vs. ANG II). These data demonstrate that ANG II increases total cardiac protein synthesis in the adult heart, leading to an attenuation in cardiac atrophy. The failure of ANG II to prevent the shift from alpha- to beta-myosin heavy chain may be related to its lack of an effect on heart rate, since other interventions that affect myosin isoenzyme distribution also increase heart rate.