COMORBIDITY OF FIBROMYALGIA WITH MEDICAL AND PSYCHIATRIC-DISORDERS
COMORBIDITY OF FIBROMYALGIA WITH MEDICAL AND PSYCHIATRIC-DISORDERS
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DOI：
10.1016/0002-9343(92)90265-d
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发表时间：
1992-04-01
影响因子：
5.9
通讯作者：
SCHLESINGER, L
中科院分区：
文献类型：
--
作者：
HUDSON, JI;GOLDENBERG, DL;SCHLESINGER, L
目的：据报道，纤维肌痛患者患有多种伴随的医学和精神疾病，包括偏头痛、肠易激综合征、慢性疲劳综合征、重度抑郁症和恐慌症。 为了进一步测试这些和其他可能的关联，我们评估了纤维肌痛患者的各种医疗和精神疾病的个人史和家族史。 患者和方法：受试者为 33 名女性（平均年龄 42.1 岁），她们均符合美国风湿病学会的纤维肌痛标准，并在三级转诊中心的风湿病专家处就诊。 他们接受了 DSM-III-R (SCID) 的结构化临床访谈； SCID 格式的补充访谈，针对其他医学和精神疾病，包括偏头痛、肠易激综合症和慢性疲劳综合症；结果：纤维肌痛患者一生中偏头痛、肠易激综合征、慢性疲劳综合征、重度抑郁症和恐慌症的发病率很高。 他们还表现出高比例的家族性严重情绪障碍。结论：偏头痛、肠易激综合征、慢性疲劳综合征、重度抑郁症和恐慌症经常与纤维肌痛共存，这一发现与这些不同的疾病可能具有共同的生理异常的假设是一致的。
PURPOSE: Patients with fibromyalgia have been reported to display high rates of several concomitant medical and psychiatric disorders, including migraine, irritable bowel syndrome, chronic fatigue syndrome, major depression, and panic disorder. To test further these and other possible associations, we assessed the personal and family histories of a broad range of medical and psychiatric disorders in patients with fibromyalgia.PATIENTS AND METHODS: Subjects were 33 women (mean age 42.1 years) who each met American College of Rheumatology criteria for fibromyalgia and presented to a rheumatologist at a tertiary referral center. They received the Structured Clinical Interview for DSM-III-R (SCID); a supplemental interview, in SCID format, for other medical and psychiatric disorders, including migraine, irritable bowel syndrome, and chronic fatigue syndrome; and an interview for family history of medical and psychiatric disorders.RESULTS: Patients with fibromyalgia displayed high lifetime rates of migraine, irritable bowel syndrome, chronic fatigue syndrome, major depression, and panic disorder. They also exhibited high rates of familial major mood disorder.CONCLUSIONS: The finding that migraine, irritable bowel syndrome, chronic fatigue syndrome, major depression, and panic disorder are frequently comorbid with fibromyalgia is consistent with the hypothesis that these various disorders may share a common physiologic abnormality.