Accelerated Monte Carlo models to simulate fluorescence spectra from layered tissues
Accelerated Monte Carlo models to simulate fluorescence spectra from layered tissues
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DOI：
10.1364/josaa.20.000714
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发表时间：
2003-04-01
影响因子：
1.9
通讯作者：
Andersson-Engels, S
中科院分区：
文献类型：
--
作者：
Swartling, J;Pifferi, A;Andersson-Engels, S
描述了两种有效的蒙特卡罗模型，便于从光散射和光吸收介质的完整的时间分辨荧光光谱的预测。这些相比，第三，传统的荧光蒙特卡罗模型的准确性，信噪比统计，和模拟时间。通过卷积技术实现了提高的计算效率，证明了问题的对称性。此外，互易原理的光子路径，采用在加速模型之一，示出了大大简化的发射荧光的分布的计算。一个所谓的白色蒙特卡罗方法，最后建议有效的模拟一个激发波长结合了广泛的发射波长。荧光是在一个纯粹的散射介质中模拟的，而吸收特性则是在分析之后考虑的。这种方法既适用于常规模型，也适用于两种加速模型。基本上相同的绝对值的荧光集成的发射表面和时间内获得的三个模型的模拟精度。的时间重新解决和空间分辨的荧光表现出轻微的高估，在短的延迟时间接近的源对应于大约两个网格元素的加速模型，作为离散化和卷积的结果。提高效率是最突出的反向发射加速模型，模拟时间可以减少两个数量级。(C)2003年美国光学学会。
Two efficient Monte Carlo models are described, facilitating predictions of complete time-resolved fluorescence spectra from a light-scattering and light-absorbing medium. These are compared with a third, conventional fluorescence Monte Carlo model in terms of accuracy, signal-to-noise statistics, and simulation time. The improved computation efficiency is achieved by means of a convolution technique, justified by the symmetry of the problem. Furthermore, the reciprocity principle for photon paths, employed in one of the accelerated models, is shown to simplify the computations of the distribution of the emitted fluorescence drastically. A so-called white Monte Carlo approach is finally suggested for efficient simulations of one excitation wavelength combined with a wide range of emission wavelengths. The fluorescence is simulated in a purely scattering medium, and the absorption properties are instead taken into account analytically afterward. This approach is applicable to the conventional model as well as to the two accelerated models. Essentially the same absolute values for the fluorescence integrated over the emitting surface and time are obtained for the three models within the accuracy of the simulations. The time-re solved and spatially resolved fluorescence exhibits a slight overestimation at short delay times close to the source corresponding to approximately two grid elements for the accelerated models, as a result of the discretization and the convolution. The improved efficiency is most prominent for the reverse-emission accelerated model, for which the simulation time can be reduced by up to two orders of magnitude. (C) 2003 Optical Society of America.