TCF/LEFs and Wnt Signaling in the Nucleus
TCF/LEFs and Wnt Signaling in the Nucleus
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DOI：
10.1101/cshperspect.a007906
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发表时间：
2012-11-01
影响因子：
7.2
通讯作者：
Waterman, Marian L.
中科院分区：
文献类型：
--
作者：
Cadigan, Ken M.;Waterman, Marian L.
T细胞因子/淋巴增强因子（TCF/LEF）转录因子是多细胞动物中Wnt/Wingless信号传导的主要终点介质。TCF/LEF是多功能蛋白质，其使用它们的序列特异性DNA结合和上下文依赖性相互作用来指定哪些基因将被Wnt调控。大部分定义其作用的工作都集中在当Wnt信号不存在时抑制靶基因表达的能力，以及当Wnt信号存在时将β-连环蛋白募集到靶基因以激活的能力。最近的进展强调了这些开/关动作是如何通过Wnt信号和稳定的β-连环蛋白来调节的。无脊椎动物通常含有一种TCF/LEF蛋白，可以激活和抑制Wnt靶标，与此相反，脊椎动物中家族的基因复制和同种型复杂性导致了特化，其中单个TCF/LEF同种型具有不同的活性。
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are multifunctional proteins that use their sequence-specific DNA-binding and context-dependent interactions to specify which genes will be regulated by Wnts. Much of the work to define their actions has focused on their ability to repress target gene expression when Wnt signals are absent and to recruit beta-catenin to target genes for activation when Wnts are present. Recent advances have highlighted how these on/off actions are regulated by Wnt signals and stabilized beta-catenin. In contrast to invertebrates, which typically contain one TCF/LEF protein that can both activate and repress Wnt targets, gene duplication and isoform complexity of the family in vertebrates have led to specialization, in which individual TCF/LEF isoforms have distinct activities.