Flybrain Neuron Database: A Comprehensive Database System of the Drosophila Brain Neurons
Flybrain Neuron Database: A Comprehensive Database System of the Drosophila Brain Neurons
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DOI：
10.1002/cne.22540
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发表时间：
2011-04-01
影响因子：
2.5
通讯作者：
Ito, Kei
中科院分区：
文献类型：
--
作者：
Shinomiya, Kazunori;Matsuda, Keiji;Ito, Kei
神经科学的悠久历史积累了有关各种生物体大脑中多种类型神经元的信息。由于此类神经元已在各种出版物中报道，且格式不受控制，因此跟踪特定神经系统中的所有已知神经元并不容易。为了解决这个问题，我们构建了一个名为 Flybrain Neuron Database (Flybrain NDB) 的在线数据库，该数据库作为收集和提供迄今为止在果蝇大脑中发布的所有类型神经元信息的平台。大脑不同区域中已识别神经元的投影模式以统一的格式记录，并尽可能提供基于文本的描述以及图像和电影。在某些情况下，投影位点以及突触后和突触前位点的分布比原始出版物中描述的更详细。有关各种抗体和表达驱动菌株的标记模式的信息，以可视化已识别的神经元，作为单独的子数据库提供。我们还实现了一种新颖的可视化工具，用户可以使用该工具以交互方式检查具有所需视角和横截面的共焦连续截面图像的三维重建。对不同出版物中报道的解剖信息的全面收集和多功能搜索功能使得分析不同大脑区域之间可能的连接成为可能。我们分析了视叶层之间的优先连接和侧角中合理的嗅觉感觉图，以显示此类数据库的有用性。 J.Comp。内罗尔。 519:807-833, 2011。(C) 2010 Wiley-Liss, Inc.
The long history of neuroscience has accumulated information about numerous types of neurons in the brain of various organisms. Because such neurons have been reported in diverse publications without controlled format, it is not easy to keep track of all the known neurons in a particular nervous system. To address this issue we constructed an online database called Flybrain Neuron Database (Flybrain NDB), which serves as a platform to collect and provide information about all the types of neurons published so far in the brain of Drosophila melanogaster. Projection patterns of the identified neurons in diverse areas of the brain were recorded in a unified format, with text-based descriptions as well as images and movies wherever possible. In some cases projection sites and the distribution of the post-and presynaptic sites were determined with greater detail than described in the original publication. Information about the labeling patterns of various antibodies and expression driver strains to visualize identified neurons are provided as a separate sub-database. We also implemented a novel visualization tool with which users can interactively examine three-dimensional reconstruction of the confocal serial section images with desired viewing angles and cross sections. Comprehensive collection and versatile search function of the anatomical information reported in diverse publications make it possible to analyze possible connectivity between different brain regions. We analyzed the preferential connectivity among optic lobe layers and the plausible olfactory sensory map in the lateral horn to show the usefulness of such a database. J. Comp. Neurol. 519:807-833, 2011. (C) 2010 Wiley-Liss, Inc.