Tumor-educated myeloid cells: impact the micro- and macroenvironment
Tumor-educated myeloid cells: impact the micro- and macroenvironment
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DOI：
10.1111/exd.12241
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发表时间：
2014-03-01
影响因子：
3.6
通讯作者：
Becker, Juergen C.
中科院分区：
文献类型：
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作者：
Becker, Juergen C.
癌症的免疫逃逸机制包括一些通常用于免疫稳态的机制，特别是那些防止自身免疫的机制;其中之一是骨髓细胞的极化。因此，肿瘤，即癌细胞和基质细胞，也通过可溶性因子和膜囊泡如外泌体调节远端部位如脾和骨髓，以产生受肿瘤训练的宏观环境。尽管这些机制目前是（肿瘤）免疫学研究的焦点，但第一个证据已经发表了近40年。这里将讨论其中一份早期报告。
Immune escape mechanisms of cancers include some of the mechanisms normally used for immune homeostasis, particular those preventing autoimmunity; one of these is the polarisation of myeloid cells. Thereby, tumors, i.e. the cancerous and stromal cells, also condition distant sites like spleen and bone marrow via soluble factors and membrane vesicles such as exosomes in order to create a tumor-educated macroenvironment. Albeit these mechanisms are currently in the focus of (tumor-)immunologic research, the first evidence had been published almost 40 years ago. One of these early reports will be discussed here.