Unclassified hepatocellular adenoma expressing ASS1 associated with inflammatory hepatocellular adenomas
Unclassified hepatocellular adenoma expressing ASS1 associated with inflammatory hepatocellular adenomas
复制标题
DOI：
10.1016/j.clinre.2019.03.012
复制
发表时间：
2019-10-01
影响因子：
2.7
通讯作者：
Bioulac-Sage, Paulette
中科院分区：
文献类型：
--
作者：
Frulio, Nora;Balabaud, Charles;Bioulac-Sage, Paulette
一名30岁的肥胖女性在妇科检查时偶然发现了三个肝结节并予以切除。具有炎性肝细胞腺瘤（HCA）组织学特征的两个结节（6和1.5 cm）呈C反应蛋白阳性，谷氨酰胺合成酶表达正常。第三个 6 厘米结节具有未分类 HCA 的所有特征，与非肿瘤肝脏相比，肿瘤中精氨基琥珀酸合酶 1 (ASS1) 过度表达。非肿瘤肝脏高度脂肪变性。经 MRI 检查，根据特定标准，两种 HCA 被鉴定为炎症性 HCA。第三个 HCA 与其他两个不同，存在特殊的瘤内液腔。这份关于表达 ASS1 的未分类 HCA 与炎症性 HCA 之间关联的第一份报告强化了 HCA 亚型发生中涉及共同因素的概念。 ASS1 是一种有趣的免疫标记物，可在未分类的 HCA 中识别出血风险高的亚组。 ASS1 过度表达会急剧减少“真正的”未分类 HCA 的数量。 (C) 2019 年由 Elsevier Masson SAS 出版。
Three liver nodules were fortuitously discovered in a 30-year-old obese woman during a gynecological workup and resected. Two nodules (6 and 1.5 cm) with histological characteristics of inflammatory hepatocellular adenoma (HCA) were C reactive protein positive with normal expression of glutamine synthetase. The third 6 cm nodule had all the characteristics of an Unclassified HCA with an overexpression of Argininosuccinate Synthase 1 (ASS1) in the tumor compared to the non-tumoral liver. The non-tumoral liver was highly steatotic. Upon MRI review, two HCAs were identified as inflammatory HCAs based on specific criteria. The third HCA was different from the other two with the presence of peculiar intratumoral fluid cavities. This first report on the association between unclassified HCA expressing ASS1 and inflammatory HCA reinforces the concept that common factors are implicated in HCA subtypes genesis. ASS1 is an interesting immuno-marker to identify among unclassified HCA a subgroup with a high risk of bleeding. ASS1 overexpression decreases sharply the number of "true" unclassified HCA. (C) 2019 Published by Elsevier Masson SAS.