Amygdalar functional connectivity during resting and evoked pain in youth with functional abdominal pain disorders.
Amygdalar functional connectivity during resting and evoked pain in youth with functional abdominal pain disorders.
复制标题
DOI：
10.1097/j.pain.0000000000002601
复制
发表时间：
2022-10-01
期刊：
影响因子：
7.4
通讯作者：
中科院分区：
文献类型：
--
作者：
小儿功能性腹痛疾病（FAPD）是一种高度流行、难以诊断和治疗的疾病，对支持FAPD的脑系统仍知之甚少。本研究探讨了在耐受良好的内脏痛诱导任务，水负荷症状激发任务（WL-SPT）的FAPD的神经机制。11至17岁的青年参加了会议。功能连接（FC）检查通过血氧水平依赖（BOLD）的影响，使用左，右杏仁核（AMY）作为种子区。评价了这些种子内的时间过程与整个大脑的体素的关系。动脉自旋标记（ASL）通过检查脑血流量来评估局部脑激活。左AMY与伤害性处理相关区域之间的FC增加（例如，在WL-SPT后的FAPD青年中观察到与认知功能（背外侧前额叶皮层）和默认模式网络（DMN;顶叶）相关的区域的右AMY FC变化。这些变化与疼痛不愉快的变化有关。WL-SPT后AMY FC的变化也与疼痛强度的变化相关。患有FAPD的年轻人的AMY FC与DMN也与健康对照不同。在FAPD和对照组之间也观察到了整体CBF的变化，但在FAPD青年组之间或WL-SPT期间，灰质均未检测到显著差异。研究结果证实，患有FAPD的青少年大脑系统发生了变化，这些变化可以支持生物标志物的开发，以增强对疼痛和治疗反应机制的理解。
Pediatric functional abdominal pain disorders (FAPD) are highly prevalent, difficult to diagnose and challenging to treat. The brain systems supporting FAPD remain poorly understood. This investigation examined the neuromechanisms of FAPD during a well-tolerated visceral pain induction task, the water load symptom provocation task (WL-SPT). Youth between the ages of 11 and 17 years participated. Functional connectivity (FC) was examined via the Blood Oxygenation Level Dependent (BOLD) effect using the left and right amygdala (AMY) as seed regions. Relationships of the time courses within these seeds with voxels across the whole brain were evaluated. Arterial spin labeling (ASL) was used to assess regional brain activation by examining cerebral blood flow. Increased FC between the left AMY with regions associated with nociceptive processing (e.g., thalamus), and right AMY FC changes with areas associated with cognitive functioning (dorsolateral prefrontal cortex) and the default mode network (DMN; parietal lobe) were observed in youth with FAPD following the WL-SPT. These changes were related to changes in pain unpleasantness. AMY FC changes post WL-SPT were also related to changes in pain intensity. AMY FC with the DMN in youth with FAPD also differed from healthy controls. Global CBF changes were also noted between FAPD and controls, but no significant differences in grey matter were detected either between groups or during the WL-SPT in youth with FAPD. Findings confirm youth with FAPD have changes in brain systems that could support the development of biomarkers to enhance understanding of the mechanisms of pain and treatment response.
登录
查看更多内容
影响因子：
5.7
作者：
Eickhoff, Simon B.;Heim, Stefan;Amunts, Katrin
通讯作者：
Amunts, Katrin
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
5.3
作者：
Baliki, Marwan N.;Chialvo, Dante R.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
8
作者：
Campo, JV;Bridge, J;Brent, DA
通讯作者：
Brent, DA
DOI：
10.1097/mpg.0b013e3181de0639
发表时间：
2010-11-01
影响因子：
2.9
作者：
Dhroove, Gati;Chogle, Ashish;Saps, Miguel
通讯作者：
Saps, Miguel