Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity
Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity
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DOI：
10.1111/febs.13053
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发表时间：
2015-05-01
期刊：
影响因子：
5.4
通讯作者：
Vaquero, Alejandro
中科院分区：
文献类型：
--
作者：
Bosch-Presegue, Laia;Vaquero, Alejandro
Sirtuins是靶向组蛋白和非组蛋白蛋白的脱乙酰酶家族，并且需要NAD（+）作为其酶促活性的酶促辅因子。这一要求赋予sirtuins检测代谢和能量稳态变化的能力，并协调细胞反应以维持基因组完整性。因此，sirtuins在环境和基因组之间的串扰中是至关重要的，因此在细胞和生物体水平上对应激的反应中也是至关重要的。Sirtuins在维持基因组完整性方面发挥重要作用，主要是通过调节表观遗传机制。它们针对不同的组蛋白标记，包括H4K16Ac，H3K9Ac，H3K56Ac和H3K18Ac，以及染色质机器的非组蛋白组分，如酶和结构蛋白。在这里，我们总结了我们目前对sirtuins和表观遗传学之间联系的看法，这反映了基因组对压力的持续适应。
Sirtuins are a family of deacetylases that target histone and non-histone proteins and require NAD(+) as an enzymatic cofactor for their enzymatic activity. This requirement confers sirtuins with the ability to detect changes in metabolism and energy homeostasis and to coordinate cellular responses to maintain genome integrity. Thus, sirtuins are crucial in the crosstalk between environment and genome, and therefore in responses to stress at the cell and organism levels. Sirtuins play a major role in maintaining genome integrity, largely through regulation of epigenetic mechanisms. They target different histone marks, including H4K16Ac, H3K9Ac, H3K56Ac and H3K18Ac, and non-histone components of the chromatin machinery, such as enzymes and structural proteins. Here we summarize our current view on the link between sirtuins and epigenetics, one that reflects the continual adaptation of the genome to stress.